EC Number | Cloned (Comment) | Organism |
---|---|---|
1.3.3.13 | the enzyme is encoded in the albonoursin biosynthetic gene cluster, albABC, genes albAB encode units for a cyclic dipeptide oxidase complex, responsible for generating two dehydrogenated double bonds | Nocardiopsis alba |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.3.3.13 | additional information | generation of an albABC gene deletion mutant YL001 of Nocardiopsis alba, genetic organization, overview. Strain YL001 show no significant difference from the wild-type in colonial morphology, and it has a slightly vibrant growth on the MS agar, production of the cyclic dipeptides is abolished in the DELTAalbABC mutant | Nocardiopsis alba |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.3.3.13 | cyclo(L-4-O-methyltyrosine-L-leucine) + 2 O2 | Nocardiopsis alba | - |
? + 2 H2O2 | - |
? | |
1.3.3.13 | cyclo(L-4-O-methyltyrosine-L-leucine) + 2 O2 | Nocardiopsis alba ATCC BAA-2165 | - |
? + 2 H2O2 | - |
? | |
1.3.3.13 | cyclo(L-leucyl-L-phenylalanyl) + 2 O2 | Nocardiopsis alba | - |
albonoursin + 2 H2O2 | - |
? | |
1.3.3.13 | cyclo(L-leucyl-L-phenylalanyl) + 2 O2 | Nocardiopsis alba ATCC BAA-2165 | - |
albonoursin + 2 H2O2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.3.3.13 | Nocardiopsis alba | - |
isolated from the guts of healthy honeybees in a year-round survey | - |
1.3.3.13 | Nocardiopsis alba ATCC BAA-2165 | - |
isolated from the guts of healthy honeybees in a year-round survey | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.3.3.13 | cyclo(L-4-O-methyltyrosine-L-leucine) + 2 O2 | - |
Nocardiopsis alba | ? + 2 H2O2 | - |
? | |
1.3.3.13 | cyclo(L-4-O-methyltyrosine-L-leucine) + 2 O2 | - |
Nocardiopsis alba ATCC BAA-2165 | ? + 2 H2O2 | - |
? | |
1.3.3.13 | cyclo(L-leucyl-L-phenylalanyl) + 2 O2 | - |
Nocardiopsis alba | albonoursin + 2 H2O2 | - |
? | |
1.3.3.13 | cyclo(L-leucyl-L-phenylalanyl) + 2 O2 | - |
Nocardiopsis alba ATCC BAA-2165 | albonoursin + 2 H2O2 | - |
? | |
1.3.3.13 | additional information | albonoursin is then methoxylated to cyclo(L-methoxytyrosine-L-leucine) by O-methyltranferases, encoded by genes B005_4460 and B005_4464, termed albM1 and albM2 | Nocardiopsis alba | ? | - |
? | |
1.3.3.13 | additional information | albonoursin is then methoxylated to cyclo(L-methoxytyrosine-L-leucine) by O-methyltranferases, encoded by genes B005_4460 and B005_4464, termed albM1 and albM2 | Nocardiopsis alba ATCC BAA-2165 | ? | - |
? |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.3.3.13 | malfunction | the albABC gene operon deletion mutant of Nocariopsis alba cannot produce cyclic dipeptides, cyclo(DELTAPhe-DELTALeu) i.e. albonoursin, and cyclo(DELTAmTyr-DELTALeu) | Nocardiopsis alba |
1.3.3.13 | metabolism | the albonoursin biosynthetic gene cluster is involved in the regulated biosynthesis of antibacterial cyclic dipeptides in Nocardiopsis alba | Nocardiopsis alba |
1.3.3.13 | physiological function | the enzyme is required for biosynthesis of antibacterial cyclic dipeptides, cyclo(DELTAPhe-DELTALeu) i.e. albonoursin, and cyclo(DELTAmTyr-DELTALeu) | Nocardiopsis alba |