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Literature summary extracted from

  • Raghuvanshi, S.; Reed, V.; Blaner, W.S.; Harrison, E.H.
    Cellular localization of ?-carotene 15,15 oxygenase-1 (BCO1) and beta-carotene 9,10 oxygenase-2 (BCO2) in rat liver and intestine (2015), Arch. Biochem. Biophys., 572, 19-27 .
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.13.11.63 cytosol
-
 Rattus norvegicus 5829
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1.13.11.63 additional information subcellular expression and localization of BCO1 and BCO2 proteins in rat liver and intestine, overview Rattus norvegicus
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-
1.13.11.71 mitochondrion
-
 Rattus norvegicus 5739
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1.13.11.71 additional information subcellular expression and localization of BCO1 and BCO2 proteins in rat liver and intestine, overview Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.71 all-trans-beta-carotene + O2 Rattus norvegicus
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 all-trans-10'-apo-beta-carotenal + beta-ionone
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.63 Rattus norvegicus Q91XT5
-
-
1.13.11.71 Rattus norvegicus A3KN98
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.63 endothelial cell
-
 Rattus norvegicus
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1.13.11.63 epithelial cell
-
 Rattus norvegicus
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1.13.11.63 hepatocyte
-
 Rattus norvegicus
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1.13.11.63 intestine immunohistochemistry shows strong BCO1 immunoreactivity in the duodenum, particularly in Brunner's glands Rattus norvegicus
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1.13.11.63 liver BCO1 is highly expressed in hepatocytes, mucosal epithelium, hepatic stellate cells, and portal endothelial cells in liver Rattus norvegicus
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1.13.11.63 McArdle-RH7777 cell
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 Rattus norvegicus
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1.13.11.63 additional information cellular expression and localization of BCO1 and BCO2 proteins in rat liver and intestine, immunohistochemic analysis, overview. BCO1 shows diffuse presence along epithelia with strong immunoreactivity in endothelial cells and in certain epithelial cells, possible intestinal retinoid storage cells Rattus norvegicus
-
1.13.11.63 stellate cell
-
 Rattus norvegicus
-
1.13.11.71 intestine
-
 Rattus norvegicus
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1.13.11.71 liver BCO2 is highly expressed in hepatocytes and mucosal epithelium Rattus norvegicus
-
1.13.11.71 McArdle-RH7777 cell
-
 Rattus norvegicus
-
1.13.11.71 additional information cellular expression and localization of BCO1 and BCO2 proteins in rat liver and intestine, immunohistochemic analysis, overview. BCO2 shows diffuse presence along epithelia with strong immunoreactivity in endothelial cells and in certain epithelial cells, possible intestinal retinoid storage cells Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.71 all-trans-beta-carotene + O2
-
 Rattus norvegicus all-trans-10'-apo-beta-carotenal + beta-ionone
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.63 BCO1
-
 Rattus norvegicus
1.13.11.71 BCO2
-
 Rattus norvegicus

General Information

EC Number General Information Comment Organism
1.13.11.63 physiological function BCO1 catalyzes central cleavage of provitamin A carotenoids at 15,15' double bond to form two molecules of all-trans-retinal which can be further metabolized to vitamin A and its derivatives Rattus norvegicus
1.13.11.71 physiological function BCO2 catalyzes eccentric cleavage of both provitamin and non-provitamin A carotenoids which results in the formation of apo-carotenoids such as beta-apo-10' carotenal and beta-ionone Rattus norvegicus