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Literature summary extracted from

  • Kim, Y.K.; Zuccaro, M.V.; Costabile, B.K.; Rodas, R.; Quadro, L.
    Tissue- and sex-specific effects of beta-carotene 15,15' oxygenase (BCO1) on retinoid and lipid metabolism in adult and developing mice (2015), Arch. Biochem. Biophys., 572, 11-18 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.63 beta-carotene + O2 Mus musculus
-
 2 all-trans-retinal
-
 ?
1.13.11.63 beta-carotene + O2 Mus musculus C57BL/6
-
 2 all-trans-retinal
-
 ?
1.13.11.71 all-trans-beta-carotene + O2 Mus musculus
-
 all-trans-10'-apo-beta-carotenal + beta-ionone
-
 ?
1.13.11.71 all-trans-beta-carotene + O2 Mus musculus C57BL/6
-
 all-trans-10'-apo-beta-carotenal + beta-ionone
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.63 Mus musculus Q9JJS6
-
-
1.13.11.63 Mus musculus C57BL/6 Q9JJS6
-
-
1.13.11.71 Mus musculus Q99NF1
-
-
1.13.11.71 Mus musculus C57BL/6 Q99NF1
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.63 adipose tissue
-
 Mus musculus
-
1.13.11.63 brain adult and embryonic, very low Bco1 expression level Mus musculus
-
1.13.11.63 embryo
-
 Mus musculus
-
1.13.11.63 eye
-
 Mus musculus
-
1.13.11.63 heart
-
 Mus musculus
-
1.13.11.63 kidney
-
 Mus musculus
-
1.13.11.63 liver adult and embryonic, high Bco1 expression level Mus musculus
-
1.13.11.63 lung
-
 Mus musculus
-
1.13.11.63 mammary gland
-
 Mus musculus
-
1.13.11.63 additional information retinoid levels in the developing liver and brain at mid-gestation, overview. BCO1-/- and wild-type female mice reveal a statistically significant decrease in retinol content in the heart, pancreas, spleen, eye and adipose tissue of the knockout females. Retinol concentrations are greater in the lungs of the BCO1-/- females compared to wild-type Mus musculus
-
1.13.11.63 pancreas
-
 Mus musculus
-
1.13.11.63 spleen
-
 Mus musculus
-
1.13.11.71 adipose tissue
-
 Mus musculus
-
1.13.11.71 brain embryonic, low Bco2 expression level Mus musculus
-
1.13.11.71 embryo
-
 Mus musculus
-
1.13.11.71 eye
-
 Mus musculus
-
1.13.11.71 heart
-
 Mus musculus
-
1.13.11.71 kidney
-
 Mus musculus
-
1.13.11.71 liver embryonic, low Bco2 expression level Mus musculus
-
1.13.11.71 additional information retinoid levels in the developing liver and brain at mid-gestation, overview Mus musculus
-
1.13.11.71 pancreas
-
 Mus musculus
-
1.13.11.71 spleen
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.63 beta-carotene + O2
-
 Mus musculus 2 all-trans-retinal
-
 ?
1.13.11.63 beta-carotene + O2
-
 Mus musculus C57BL/6 2 all-trans-retinal
-
 ?
1.13.11.71 all-trans-beta-carotene + O2
-
 Mus musculus all-trans-10'-apo-beta-carotenal + beta-ionone
-
 ?
1.13.11.71 all-trans-beta-carotene + O2
-
 Mus musculus C57BL/6 all-trans-10'-apo-beta-carotenal + beta-ionone
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.63 BCO1
-
 Mus musculus
1.13.11.63 beta-carotene 15,15' oxygenase
-
 Mus musculus
1.13.11.63 beta-carotene 15,15'-oxygenase
-
 Mus musculus
1.13.11.71 BCO2
-
 Mus musculus
1.13.11.71 beta-carotene-9',10'-oxygenase
-
 Mus musculus

General Information

EC Number General Information Comment Organism
1.13.11.63 malfunction deficiency of BCO1 in the liver does not significantly affect retinol or retinyl ester concentrations compared to the wild-type group, even though retinyl ester levels tend to be lower in the absence of BCO1. BCO1-/- and wild-type female mice reveal a statistically significant decrease in retinol content in the heart, pancreas, spleen, eye and adipose tissue of the knockout females. Retinol concentrations are greater in the lungs of the BCO1-/- females compared to wild-type Mus musculus