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Literature summary extracted from

  • Kiss, F.M.; Schmitz, D.; Zapp, J.; Dier, T.K.; Volmer, D.A.; Bernhardt, R.
    Comparison of CYP106A1 and CYP106A2 from Bacillus megaterium - identification of a novel 11-oxidase activity (2015), Appl. Microbiol. Biotechnol., 99, 8495-8514 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.15.8 expression in Escherichia coli Priestia megaterium

Organism

EC Number Organism UniProt Comment Textmining
1.14.15.8 Priestia megaterium
-
-
-
1.14.15.8 Priestia megaterium Q06069 isoform Cyp106A2
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.15.8 11-deoxycorticosterone + reduced adrenodoxin + O2
-
Priestia megaterium 15beta-hydroxy-11-deoxycorticosterone + 7beta,15beta-dihydroxy-11-deoxycorticosterone + oxidized adrenodoxin + H2O
-
?
1.14.15.8 11-deoxycortisol + reduced adrenodoxin + O2
-
Priestia megaterium 15beta-hydroxy-11-deoxycortisol + oxidized adrenodoxin + H2O
-
?
1.14.15.8 11beta-hydroxy-4-androstene-3,17-dione + reduced adrenodoxin + O2
-
Priestia megaterium ? + oxidized adrenodoxin + H2O
-
?
1.14.15.8 17alpha-methyltestosterone + reduced adrenodoxin + O2
-
Priestia megaterium ? + oxidized adrenodoxin + H2O
-
?
1.14.15.8 19-nortestosterone + reduced adrenodoxin + O2
-
Priestia megaterium ? + oxidized adrenodoxin + H2O
-
?
1.14.15.8 4-androstene-3,17-dione + reduced adrenodoxin + O2
-
Priestia megaterium 15beta-hydroxyandrostene-3,17-dione + oxidized adrenodoxin + H2O
-
?
1.14.15.8 corticosterone + reduced adrenodoxin + O2
-
Priestia megaterium 15beta-hydroxycorticosterone + oxidized adrenodoxin + H2O
-
?
1.14.15.8 cortisone + reduced adrenodoxin + O2
-
Priestia megaterium 15beta-hydroxycortisone + oxidized adrenodoxin + H2O
-
?
1.14.15.8 dexamethasone + reduced adrenodoxin + O2
-
Priestia megaterium ? + oxidized adrenodoxin + H2O
-
?
1.14.15.8 additional information enzyme produces hydroxylated metabolites at positions 6beta, 7beta, 9alpha, and 15beta and shows additionally 11-oxidase activity. No substrates: beta-estradiol, estrone, adrenosterone, and 19-hydroxyandrostenedione Priestia megaterium ?
-
?
1.14.15.8 additional information enzyme produces hydroxylated metabolites at positions 6beta, 7beta, 9alpha,and 15beta and shows additionally 11-oxidase activity. No substrates: beta-estradiol, estrone, adrenosterone, and 19-hydroxyandrostenedione Priestia megaterium ?
-
?
1.14.15.8 prednisolone + reduced adrenodoxin + O2
-
Priestia megaterium ? + oxidized adrenodoxin + H2O
-
?
1.14.15.8 prednisone + reduced adrenodoxin + O2
-
Priestia megaterium ? + oxidized adrenodoxin + H2O
-
?
1.14.15.8 testosterone + reduced adrenodoxin + O2
-
Priestia megaterium 15beta-hydroxytestosterone + oxidized adrenodoxin + H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.15.8 Cyp106A1
-
Priestia megaterium
1.14.15.8 CYP106A2
-
Priestia megaterium

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.15.8 heme steroids beta-estradiol, estrone, pregnenolone and 17alpha-hydroxypregnenolone, do not shift the heme iron into the high-spin form Priestia megaterium