Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Caceres, C.J.; Angulo, J.; Contreras, N.; Pino, K.; Vera-Otarola, J.; Lopez-Lastra, M.
    Targeting deoxyhypusine hydroxylase activity impairs cap-independent translation initiation driven by the 5'untranslated region of the HIV-1, HTLV-1, and MMTV mRNAs (2016), Antiviral Res., 134, 192-206 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.99.29 ciclopirox
-
 Homo sapiens
1.14.99.29 deferiprone
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.99.29 [eIF5A]-deoxyhypusine + AH2 + O2 Homo sapiens
-
 [eIF5A]-hypusine + A + H2O
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
1.14.99.29 Homo sapiens Q9BU89
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.99.29 HEK-293T cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.99.29 [eIF5A]-deoxyhypusine + AH2 + O2
-
 Homo sapiens [eIF5A]-hypusine + A + H2O
-
 ir

Subunits

EC Number Subunits Comment Organism
1.14.99.29 ? x * 35000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.14.99.29 deoxyhypusine hydroxylase
-
 Homo sapiens
1.14.99.29 DOHH
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.14.99.29 physiological function the cellular concentration of the enzyme and its enzymatic activity play a role in HIV-1, HTLV-1 and MMTV IRES-mediated translation initiation Homo sapiens