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Literature summary extracted from

  • Ghorbani, S.; Fossbakk, A.; Jorge-Finnigan, A.; Flydal, M.I.; Haavik, J.; Kleppe, R.
    Regulation of tyrosine hydroxylase is preserved across different homo- and heterodimeric 14-3-3 proteins (2016), Amino Acids, 48, 1221-1229 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.16.2 14-3-3gamma homodimeric 14-3-3gamma protein is the strongest activator Homo sapiens
1.14.16.2 14-3-3gamma protein homodimeric 14-3-3gamma protein is the strongest activator Bos taurus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.16.2 expressed in Escherichia coli BL21 Codon Plus (DE3) cells Bos taurus
1.14.16.2 expressed in Escherichia coli BL21 Codon Plus (DE3) cells Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.16.2 L-tyrosine + tetrahydrobiopterin + O2 Bos taurus
-
 L-dopa + 4a-hydroxytetrahydrobiopterin + H2O
-
 ?
1.14.16.2 L-tyrosine + tetrahydrobiopterin + O2 Homo sapiens
-
 L-dopa + 4a-hydroxytetrahydrobiopterin + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.16.2 Bos taurus
-
-
-
1.14.16.2 Homo sapiens P07101
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.14.16.2 phosphoprotein phosphorylation at Ser19 Bos taurus
1.14.16.2 phosphoprotein phosphorylation at Ser19 Homo sapiens

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.16.2 Ni-NTA column chromatography and Superdex 200 gel filtration Bos taurus
1.14.16.2 Ni-NTA column chromatography and Superdex 200 gel filtration Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.16.2 L-tyrosine + tetrahydrobiopterin + O2
-
 Bos taurus L-dopa + 4a-hydroxytetrahydrobiopterin + H2O
-
 ?
1.14.16.2 L-tyrosine + tetrahydrobiopterin + O2
-
 Homo sapiens L-dopa + 4a-hydroxytetrahydrobiopterin + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.16.2 tyrosine hydroxylase
-
 Bos taurus
1.14.16.2 tyrosine hydroxylase
-
 Homo sapiens