BRENDA - Enzyme Database show

Intrinsic carnosine metabolism in the human kidney

Peters, V.; Klessens, C.Q.; Baelde, H.J.; Singler, B.; Veraar, K.A.; Zutinic, A.; Drozak, J.; Zschocke, J.; Schmitt, C.P.; de Heer, E.; Amino Acids 47, 2541-2550 (2015)

Data extracted from this reference:

Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
6.3.2.11
Mg2+
required
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
6.3.2.11
ATP + L-histidine + beta-alanine
Homo sapiens
-
ADP + phosphate + carnosine
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
6.3.2.11
Homo sapiens
A5YM72
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
6.3.2.11
brain
-
Homo sapiens
-
6.3.2.11
cell culture
primary kidney cells
Homo sapiens
-
6.3.2.11
heart
-
Homo sapiens
-
6.3.2.11
HK-2 cell
-
Homo sapiens
-
6.3.2.11
HUVEC cell
-
Homo sapiens
-
6.3.2.11
kidney
primarily in proximal tubules, CARNS is expressed in glomeruli and tubular cells, close to the apical membrane
Homo sapiens
-
6.3.2.11
additional information
carnosine-synthesizing and carnosine-hydrolyzing enzymes are localized in distinct compartments in the nephron, enzyme localization study, overview
Homo sapiens
-
6.3.2.11
podocyte
-
Homo sapiens
-
6.3.2.11
skeletal muscle
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
6.3.2.11
ATP + L-histidine + beta-alanine
-
744004
Homo sapiens
ADP + phosphate + carnosine
-
-
-
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
6.3.2.11
ATP
-
Homo sapiens
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
6.3.2.11
ATP
-
Homo sapiens
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
6.3.2.11
Mg2+
required
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
6.3.2.11
ATP + L-histidine + beta-alanine
Homo sapiens
-
ADP + phosphate + carnosine
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
6.3.2.11
brain
-
Homo sapiens
-
6.3.2.11
cell culture
primary kidney cells
Homo sapiens
-
6.3.2.11
heart
-
Homo sapiens
-
6.3.2.11
HK-2 cell
-
Homo sapiens
-
6.3.2.11
HUVEC cell
-
Homo sapiens
-
6.3.2.11
kidney
primarily in proximal tubules, CARNS is expressed in glomeruli and tubular cells, close to the apical membrane
Homo sapiens
-
6.3.2.11
additional information
carnosine-synthesizing and carnosine-hydrolyzing enzymes are localized in distinct compartments in the nephron, enzyme localization study, overview
Homo sapiens
-
6.3.2.11
podocyte
-
Homo sapiens
-
6.3.2.11
skeletal muscle
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
6.3.2.11
ATP + L-histidine + beta-alanine
-
744004
Homo sapiens
ADP + phosphate + carnosine
-
-
-
?
General Information
EC Number
General Information
Commentary
Organism
6.3.2.11
physiological function
histidine-containing dipeptides like carnosine and anserine have protective functions in both health and disease. Carnosine is synthesized by the enzyme carnosine synthase (CARNS), which is present in skeletal and heart muscle, as well as in certain regions in the brain and kidney
Homo sapiens
General Information (protein specific)
EC Number
General Information
Commentary
Organism
6.3.2.11
physiological function
histidine-containing dipeptides like carnosine and anserine have protective functions in both health and disease. Carnosine is synthesized by the enzyme carnosine synthase (CARNS), which is present in skeletal and heart muscle, as well as in certain regions in the brain and kidney
Homo sapiens