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Literature summary extracted from

  • von Koschitzky, I.; Gerhardt, H.; Laemmerhofer, M.; Kohout, M.; Gehringer, M.; Laufer, S.; Pink, M.; Schmitz-Spanke, S.; Strube, C.; Kaiser, A.
    New insights into novel inhibitors against deoxyhypusine hydroxylase from Plasmodium falciparum compounds with an iron chelating potential (2015), Amino Acids, 47, 1155-1166 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.99.29 expressed in Escherichia coli BL21 cells Plasmodium falciparum

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.99.29 2-(4-methoxyphenyl)-6-[[2-(4-methoxyphenyl)-3H-benzimidazol-5-yl]methyl]-1H-benzimidazole 94.1% inhibition at 0.002 mM Plasmodium falciparum
1.14.99.29 N-phenyl-1-[1-(phenylmethyl)benzimidazol-2-yl]diazenylnaphthalen-2-amine 87.6% inhibition at 0.002 mM Plasmodium falciparum
1.14.99.29 N-[4-(3,4-diethoxyphenyl)-1,2,5-oxadiazole-3-yl]-3-methylbenzamide 92.6% inhibition at 0.002 mM Plasmodium falciparum
1.14.99.29 zileuton i.e. N-[1-(1-benzothien-2-yl)ethyl]-N-hydroxyurea Plasmodium falciparum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.99.29 [eIF5A]-deoxyhypusine + AH2 + O2 Plasmodium falciparum
-
 [eIF5A]-hypusine + A + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.99.29 Plasmodium falciparum
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.99.29 Ni-NTA column chromatography, and Superdex 200 gel filtration Plasmodium falciparum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.99.29 [eIF5A]-deoxyhypusine + AH2 + O2
-
 Plasmodium falciparum [eIF5A]-hypusine + A + H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
1.14.99.29 ? x * 42000, SDS-PAGE Plasmodium falciparum

Synonyms

EC Number Synonyms Comment Organism
1.14.99.29 deoxyhypusine hydroxylase
-
 Plasmodium falciparum
1.14.99.29 DOHH
-
 Plasmodium falciparum