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Literature summary extracted from

  • Cala, A.R.; Nadeau, M.T.; Abendroth, J.; Staker, B.L.; Reers, A.R.; Weatherhead, A.W.; Dobson, R.C.; Myler, P.J.; Hudson, A.O.
    The crystal structure of dihydrodipicolinate reductase from the human-pathogenic bacterium Bartonella henselae strain Houston-1 at 2.3 A resolution (2016), Acta Crystallogr. Sect. F, 72, 885-891 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.17.1.8 expression in Escherichia coli BL21 (DE3) R3 Rosetta cells Bartonella henselae

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.17.1.8 sitting-drop vapor-diffusion, protein crystals are grown in conditions consisting of 5%(w/v) PEG 4000, 200 mM sodium acetate, 100 mM sodium citrate tribasic pH 5.5 and are shown to diffract to about 2.3 A resolution. They belong to space group P4(3)22, with unit cell parameters a = 109.38, b = 109.38, c = 176.95 A Bartonella henselae

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.17.1.8 28000
-
 SDS-PAGE Bartonella henselae
1.17.1.8 114000
-
 size-exclusion chromatography Bartonella henselae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ Bartonella henselae the enzyme catalyzes the second committed step in the diaminopimelate/lysine anabolic pathways (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O
-
 ?
1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ Bartonella henselae Houston 1 the enzyme catalyzes the second committed step in the diaminopimelate/lysine anabolic pathways (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.17.1.8 Bartonella henselae Q6G2G3
-
-
1.17.1.8 Bartonella henselae Houston 1 Q6G2G3
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.17.1.8
-
 Bartonella henselae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ the enzyme catalyzes the second committed step in the diaminopimelate/lysine anabolic pathways Bartonella henselae (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O
-
 ?
1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ the enzyme catalyzes the second committed step in the diaminopimelate/lysine anabolic pathways Bartonella henselae Houston 1 (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
1.17.1.8 tetramer 4 * 28000, SDS-PAGE Bartonella henselae

Synonyms

EC Number Synonyms Comment Organism
1.17.1.8 DapB
-
 Bartonella henselae

General Information

EC Number General Information Comment Organism
1.17.1.8 metabolism the enzyme catalyzes the second committed step in the diaminopimelate/lysine anabolic pathways Bartonella henselae