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Literature summary extracted from

  • Edgar, S.; Li, F.S.; Qiao, K.; Weng, J.K.; Stephanopoulos, G.
    Engineering of taxadiene synthase for improved selectivity and yield of a key taxol biosynthetic intermediate (2017), ACS Synth. Biol., 6, 201-205 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.176 taxa-4(20)-11(12)-diene + AH2 + O2 Taxus sp.
-
 ?
-
 ?
1.14.14.176 taxa-4,11-diene + [reduced NADPH-hemoprotein reductase] + O2 Taxus sp.
-
 taxa-4(20),11(12)-dien-5alpha-ol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
4.2.3.17 geranylgeranyl diphosphate Taxus brevifolia
-
 taxa-4,11-diene + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.176 Taxus sp.
-
-
-
4.2.3.17 Taxus brevifolia Q41594
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.176 taxa-4(20)-11(12)-diene + AH2 + O2
-
 Taxus sp. ?
-
 ?
1.14.14.176 taxa-4,11-diene + [reduced NADPH-hemoprotein reductase] + O2
-
 Taxus sp. taxa-4(20),11(12)-dien-5alpha-ol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
4.2.3.17 geranylgeranyl diphosphate
-
 Taxus brevifolia taxa-4,11-diene + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.176 CYP725A4
-
 Taxus sp.
1.14.14.176 taxadien-5alpha-hydroxylase
-
 Taxus sp.
1.14.14.176 taxadiene synthase
-
 Taxus sp.
4.2.3.17 TXS
-
 Taxus brevifolia

General Information

EC Number General Information Comment Organism
4.2.3.17 metabolism key enzyme in directing pathway flux toward taxol precursors, such as taxadien-5alpha-ol Taxus brevifolia