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Literature summary extracted from

  • Sogi, K.M.; Holsclaw, C.M.; Fragiadakis, G.K.; Nomura, D.K.; Leary, J.A.; Bertozzi, C.R.
    Biosynthesis and regulation of sulfomenaquinone, a metabolite associated with virulence in Mycobacterium tuberculosis (2016), ACS Infect. Dis., 2, 800-806 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.15.27 beta-dihydromenaquinone-9 + 2 reduced ferredoxin [iron-sulfur] cluster + O2 Mycobacterium tuberculosis
-
 omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
 ?
1.14.15.27 beta-dihydromenaquinone-9 + 2 reduced ferredoxin [iron-sulfur] cluster + O2 Mycobacterium tuberculosis H37Rv
-
 omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.15.27 Mycobacterium tuberculosis P9WPN7
-
-
1.14.15.27 Mycobacterium tuberculosis H37Rv P9WPN7
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.15.27 beta-dihydromenaquinone-9 + 2 reduced ferredoxin [iron-sulfur] cluster + O2
-
 Mycobacterium tuberculosis omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
 ?
1.14.15.27 beta-dihydromenaquinone-9 + 2 reduced ferredoxin [iron-sulfur] cluster + O2
-
 Mycobacterium tuberculosis H37Rv omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.15.27 cyp128
-
 Mycobacterium tuberculosis
1.14.15.27 Rv2268c
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 Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
1.14.15.27 physiological function Cyp128 and sulfotransferase Stf 3 are sufficient for the biosynthesis of sulfomenaquinone from menaquinone in recombinant Mycobacterium smegmatis. In a mouse model of infection the loss of Cyp128 exhibits a hypervirulent phenotype similar to that in previous studies of the Stf 3 mutant Mycobacterium tuberculosis