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Literature summary extracted from

  • Sacchi, S.; Novellis, V.; Paolone, G.; Nuzzo, T.; Iannotta, M.; Belardo, C.; Squillace, M.; Bolognesi, P.; Rosini, E.; Motta, Z.; Frassineti, M.; Bertolino, A.; Pollegioni, L.; Morari, M.; Maione, S.; Errico, F.; Usiello, A.
    Olanzapine, but not clozapine, increases glutamate release in the prefrontal cortex of freely moving mice by inhibiting D-aspartate oxidase activity (2017), Sci. Rep., 7, 46288 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.1 additional information not inhibited by clozapine, chlorpromazine, haloperidol, bupropion, fluoxetine, and amitriptyline Homo sapiens
1.4.3.1 additional information not inhibited by clozapine, chlorpromazine, haloperidol, bupropion, fluoxetine, and amitriptyline Mus musculus
1.4.3.1 olanzapine
-
 Homo sapiens
1.4.3.1 olanzapine
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.3.1 D-aspartate + H2O + O2 Mus musculus
-
 oxaloacetate + NH3 + H2O2
-
 ?
1.4.3.1 D-aspartate + H2O + O2 Homo sapiens
-
 oxaloacetate + NH3 + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.1 Homo sapiens Q99489
-
-
1.4.3.1 Mus musculus Q0E9Q7
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.1 brain
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.1 D-aspartate + H2O + O2
-
 Mus musculus oxaloacetate + NH3 + H2O2
-
 ?
1.4.3.1 D-aspartate + H2O + O2
-
 Homo sapiens oxaloacetate + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.1 DDO
-
 Mus musculus
1.4.3.1 DDO
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.4.3.1 0.0014
-
 in the presence of 0.004 mM FAD, pH and temperature not specified in the publication Mus musculus olanzapine
1.4.3.1 0.0231
-
 in the presence of 0.004 mM FAD, pH and temperature not specified in the publication Homo sapiens olanzapine