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Literature summary extracted from

  • Kumar, N.; Gupta, G.; Anilkumar, K.; Fatima, N.; Karnati, R.; Reddy, G.; Giri, P.; Reddanna, P.
    15-Lipoxygenase metabolites of alpha-linolenic acid, [13-(S)-HPOTrE and 13-(S)-HOTrE], mediate anti-inflammatory effects by inactivating NLRP3 inflammasome (2016), Sci. Rep., 6, 31649 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.33 arachidonate + O2 Mus musculus best substrate (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate
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1.13.11.33 arachidonate + O2 Mus musculus BALB/c best substrate (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate
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Organism

EC Number Organism UniProt Comment Textmining
1.13.11.33 Mus musculus P39654
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1.13.11.33 Mus musculus BALB/c P39654
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.33 RAW-264.7 cell
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Mus musculus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.33 alpha-linolenate + O2
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Mus musculus (9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoic acid + (9Z,11E,13S,15Z)-13-hydroxyoctadeca-9,11,15-trienoic acid
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?
1.13.11.33 alpha-linolenate + O2
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Mus musculus BALB/c (9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoic acid + (9Z,11E,13S,15Z)-13-hydroxyoctadeca-9,11,15-trienoic acid
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?
1.13.11.33 arachidonate + O2 best substrate Mus musculus (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate
-
?
1.13.11.33 arachidonate + O2 best substrate Mus musculus BALB/c (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate
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?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.33 15-lipoxygenase
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Mus musculus
1.13.11.33 15-LOX
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Mus musculus

General Information

EC Number General Information Comment Organism
1.13.11.33 physiological function the effects of 15-LOX-generated metabolites of alpha-linolenic acid on lipopolysaccharide-induced inflammation in RAW 264.7 cells and peritoneal macrophages, analysis of the effect of these metabolites on the survival of BALB/c mice in LPS mediated septic shock and also polymicrobial sepsis in Cecal Ligation and Puncture mouse model, overview. Anti-inflammatory effects of 13-(S)-hydroperoxyoctadecatrienoic acid and 13-(S)-hydroxyoctadecatrienoic acid by inactivating NLRP3 inflammasome complex through the PPAR-gama pathway. Both metabolites, especially 13-(S)-hydroperoxyoctadecatrienoic acid, also deactivate autophagy and induce apoptosis Mus musculus