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Literature summary extracted from

  • Margaryan, H.; Dorosh, A.; Capkova, J.; Manaskova-Postlerova, P.; Philimonenko, A.; Hozak, P.; Peknicova, J.
    Characterization and possible function of glyceraldehyde-3-phosphate dehydrogenase-spermatogenic protein GAPDHS in mammalian sperm (2015), Reprod. Biol. Endocrinol., 13, 15 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.12 D-glyceraldehyde 3-phosphate + phosphate + NAD+ Homo sapiens
-
 3-phospho-D-glyceroyl phosphate + NADH + H+
-
 r
1.2.1.12 D-glyceraldehyde 3-phosphate + phosphate + NAD+ Mus musculus
-
 3-phospho-D-glyceroyl phosphate + NADH + H+
-
 r
1.2.1.12 D-glyceraldehyde 3-phosphate + phosphate + NAD+ Mus musculus BALB/c
-
 3-phospho-D-glyceroyl phosphate + NADH + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.12 Homo sapiens O14556
-
-
1.2.1.12 Mus musculus Q64467
-
-
1.2.1.12 Mus musculus BALB/c Q64467
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.12 sperm cell ejaculated sperm cells, localization of the GAPDHS protein in the sperm head, immunologic analysis, in the principal piece and acrosomal part of the sperm cells, overview Homo sapiens
-
1.2.1.12 sperm cell epididymal spermatozoa, localization of the GAPDHS protein in the sperm head, immunologic analysis, in the principal piece and acrosomal part of the sperm cells, overview Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.12 D-glyceraldehyde 3-phosphate + phosphate + NAD+
-
 Homo sapiens 3-phospho-D-glyceroyl phosphate + NADH + H+
-
 r
1.2.1.12 D-glyceraldehyde 3-phosphate + phosphate + NAD+
-
 Mus musculus 3-phospho-D-glyceroyl phosphate + NADH + H+
-
 r
1.2.1.12 D-glyceraldehyde 3-phosphate + phosphate + NAD+
-
 Mus musculus BALB/c 3-phospho-D-glyceroyl phosphate + NADH + H+
-
 r

Subunits

EC Number Subunits Comment Organism
1.2.1.12 ? x * 75000, about, recombinant enzyme, SDS-PAGE, x * 45000-50000, native enzyme, SDS-PAGE Homo sapiens
1.2.1.12 ? x * 75000, about, recombinant enzyme, SDS-PAGE, x * 45000-50000, native enzyme, SDS-PAGE Mus musculus

Synonyms

EC Number Synonyms Comment Organism
1.2.1.12 D-glyceraldehyde-3-phosphate dehydrogenase
-
 Mus musculus
1.2.1.12 GAPDH
-
 Mus musculus
1.2.1.12 GAPDHS
-
 Homo sapiens
1.2.1.12 glyceraldehyde-3-phosphate dehydrogenase-spermatogenic protein
-
 Homo sapiens
1.2.1.12 glyceraldehyde-3-phosphate dehydrogenase-spermatogenic protein GAPDHS
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.12 NAD+
-
 Homo sapiens
1.2.1.12 NAD+
-
 Mus musculus
1.2.1.12 NADH
-
 Homo sapiens
1.2.1.12 NADH
-
 Mus musculus

General Information

EC Number General Information Comment Organism
1.2.1.12 physiological function glyceraldehyde-3-phosphate dehydrogenase-spermatogenic protein, GAPDHS, is a sperm-specific glycolytic enzyme involved in energy production during spermatogenesis and sperm motility Homo sapiens
1.2.1.12 physiological function glyceraldehyde-3-phosphate dehydrogenase-spermatogenic protein, GAPDHS, is a sperm-specific glycolytic enzyme involved in energy production during spermatogenesis and sperm motility Mus musculus