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Literature summary extracted from

  • Fink, M.L.; Chung, S.I.; Folk, J.E.
    gamma-Glutamylamine cyclotransferase specificity toward epsilon-(L-gamma-glutamyl)-L-lysine and related compounds (1980), Proc. Natl. Acad. Sci. USA, 77, 4564-4568 .
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.3.2.8 0.23
-
 epsilon-(gamma-L-glutamyl)-L-lysine pH 7.5, 37°C Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.3.2.8 epsilon-(gamma-L-glutamyl)-L-lysine Oryctolagus cuniculus
-
 L-lysine + 5-oxo-L-proline
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.3.2.8 Oryctolagus cuniculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.3.2.8 partial Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.3.2.8 kidney
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.2.8 alpha-N-acetyl-epsilon-(L-gamma-glutamyl)-L-lysine methyl ester
-
 Oryctolagus cuniculus alpha-N-acetyl-L-lysine + 5-oxo-L-proline
-
 ?
4.3.2.8 epsilon-(gamma-L-glutamyl)-D-lysine
-
 Oryctolagus cuniculus D-lysine + 5-oxo-L-proline
-
 ?
4.3.2.8 epsilon-(gamma-L-glutamyl)-L-lysine
-
 Oryctolagus cuniculus L-lysine + 5-oxo-L-proline
-
 ?
4.3.2.8 L-gamma-glutamyl-n-butylamine
-
 Oryctolagus cuniculus n-butylamine + 5-oxo-L-proline
-
 ?
4.3.2.8 L-gamma-glutamylputrescine
-
 Oryctolagus cuniculus putrescine + 5-oxo-L-proline
-
 ?
4.3.2.8 additional information no activity toward alpha-(gamma-L-glutamyl)-L-amino acids or on epsilon-(D-gamma-glutamyl)-L-lysine, epsilon-(L-beta-aspartyl)-L-lysine, epsilon-(D,L-beta-aminoglutaryl)-L-lysine, L-glutamine, alpha-N-acetyl-epsilon-[L-alpha-glutamylglycine]-L-lysine methyl ester, alpha-N-acetyl-epsilon-(gamma-L-alpha-glutamyl-L-valine ethyl ester)-L-lysine methyl ester, N-[gamma-(L-alpha-glutamylglycylglycylglycine)]isobutylamine, epsilon-acetyl-L-lysine, epsilon-formyl-L-lysine, and L-gamma-glutamyl-p-nitroanilide Oryctolagus cuniculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.3.2.8 GGACT
-
 Oryctolagus cuniculus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
4.3.2.8 6.8 8.5
-
 Oryctolagus cuniculus