Literature summary extracted from

Adel, S.; Karst, F.; Gonzalez-Lafont, A.; Pekarova, M.; Saura, P.; Masgrau, L.; Lluch, J.M.; Stehling, S.; Horn, T.; Kuhn, H.; Heydeck, D.
Evolutionary alteration of ALOX15 specificity optimizes the biosynthesis of antiinflammatory and proresolving lipoxins (2016), Proc. Natl. Acad. Sci. USA, 113, E4266-E4275 .

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
1.13.11.31	sequence comparisons and phylogenetic analysis	Homo sapiens
1.13.11.31	sequence comparisons and phylogenetic analysis	Macaca mulatta
1.13.11.31	sequence comparisons and phylogenetic analysis	Nomascus leucogenys
1.13.11.31	sequence comparisons and phylogenetic analysis	Oryctolagus cuniculus
1.13.11.31	sequence comparisons and phylogenetic analysis	Pan paniscus
1.13.11.31	sequence comparisons and phylogenetic analysis	Pan troglodytes
1.13.11.31	sequence comparisons and phylogenetic analysis	Papio anubis
1.13.11.31	sequence comparisons and phylogenetic analysis	Pongo abelii
1.13.11.31	sequence comparisons and phylogenetic analysis	Pongo pygmaeus
1.13.11.33	sequence comparisons and phylogenetic analysis	Homo sapiens
1.13.11.33	sequence comparisons and phylogenetic analysis	Macaca mulatta
1.13.11.33	sequence comparisons and phylogenetic analysis	Nomascus leucogenys
1.13.11.33	sequence comparisons and phylogenetic analysis	Oryctolagus cuniculus
1.13.11.33	sequence comparisons and phylogenetic analysis	Pan paniscus
1.13.11.33	sequence comparisons and phylogenetic analysis	Pan troglodytes
1.13.11.33	sequence comparisons and phylogenetic analysis	Papio anubis
1.13.11.33	sequence comparisons and phylogenetic analysis	Pongo abelii
1.13.11.33	sequence comparisons and phylogenetic analysis	Pongo pygmaeus

Protein Variants

EC Number	Protein Variants	Comment	Organism
1.13.11.31	I417A	naturally occuring mutation, the mutant produces 94% 12-hydroperoxyicosatetraenoate and 6% 15-hydroperoxyicosatetraenoate, in contrast to the wild-type, that produces 15% 12-hydroperoxyicosatetraenoate and 85% 15-hydroperoxyicosatetraenoate	Homo sapiens
1.13.11.31	I417A	naturally occuring mutation, the mutant produces 82% 12-hydroperoxyicosatetraenoate and 18% 15-hydroperoxyicosatetraenoate, in contrast to the wild-type, that produces 14% 12-hydroperoxyicosatetraenoate and 86% 15-hydroperoxyicosatetraenoate	Pongo pygmaeus
1.13.11.31	I418A	naturally occuring mutation, the mutant produces exclusively 12-hydroperoxyicosatetraenoate and almost no 15-hydroperoxyicosatetraenoate, in contrast to the wild-type, that produces about equal amounts of both	Nomascus leucogenys
1.13.11.31	I418A	naturally occuring mutation, the mutant produces 92% 12-hydroperoxyicosatetraenoate and 8% 15-hydroperoxyicosatetraenoate, in contrast to the wild-type, that produces 3% 12-hydroperoxyicosatetraenoate and 97% 15-hydroperoxyicosatetraenoate	Oryctolagus cuniculus
1.13.11.31	I418F	naturally occuring mutation, the mutant produces more 15-hydroperoxyicosatetraenoate compared to 12-hydroperoxyicosatetraenoate, in contrast to the wild-type, that produces about equal amounts of both	Nomascus leucogenys
1.13.11.31	I419A	naturally occuring mutation, the mutant produces exclusively 12-hydroperoxyicosatetraenoate and almost no 15-hydroperoxyicosatetraenoate, in contrast to the wild-type, that produces about 80% 15-hydroperoxyicosatetraenoate	Pan troglodytes
1.13.11.31	M419T	naturally occuring mutation, the mutant produces more 12-hydroperoxyicosatetraenoate compared to 15-hydroperoxyicosatetraenoate, incontrast to the wild-type, inversed substrate specificity	Homo sapiens
1.13.11.31	T594V	naturally occuring mutation, the mutant produces more 12-hydroperoxyicosatetraenoate compared to 15-hydroperoxyicosatetraenoate, incontrast to the wild-type, inversed substrate specificity	Homo sapiens
1.13.11.33	I417A	naturally occuring mutation, the mutant produces 82% 12-hydroperoxyicosatetraenoate and 18% 15-hydroperoxyicosatetraenoate, in contrast to the wild-type, that produces 14% 12-hydroperoxyicosatetraenoate and 86% 15-hydroperoxyicosatetraenoate	Pongo pygmaeus
1.13.11.33	I417A	naturally occuring mutation, the mutant produces 94% 12-hydroperoxyicosatetraenoate and 6% 15-hydroperoxyicosatetraenoate, in contrast to the wild-type, that produces 15% 12-hydroperoxyicosatetraenoate and 85% 15-hydroperoxyicosatetraenoate	Homo sapiens
1.13.11.33	I418A	naturally occuring mutation, the mutant produces 92% 12-hydroperoxyicosatetraenoate and 8% 15-hydroperoxyicosatetraenoate, in contrast to the wild-type, that produces 3% 12-hydroperoxyicosatetraenoate and 97% 15-hydroperoxyicosatetraenoate	Oryctolagus cuniculus
1.13.11.33	I418A	naturally occuring mutation, the mutant produces exclusively 12-hydroperoxyicosatetraenoate and almost no 15-hydroperoxyicosatetraenoate, in contrast to the wild-type, that produces about equal amounts of both	Nomascus leucogenys
1.13.11.33	I418F	naturally occuring mutation, the mutant produces more 15-hydroperoxyicosatetraenoate compared to 12-hydroperoxyicosatetraenoate, in contrast to the wild-type, that produces about equal amounts of both	Nomascus leucogenys
1.13.11.33	I419A	naturally occuring mutation, the mutant produces exclusively 12-hydroperoxyicosatetraenoate and almost no 15-hydroperoxyicosatetraenoate, in contrast to the wild-type, that produces about 80% 15-hydroperoxyicosatetraenoate	Pan troglodytes
1.13.11.33	M419T	naturally occuring mutation, the mutant produces more 12-hydroperoxyicosatetraenoate compared to 15-hydroperoxyicosatetraenoate, incontrast to the wild-type, inversed substrate specificity	Homo sapiens
1.13.11.33	T594V	naturally occuring mutation, the mutant produces more 12-hydroperoxyicosatetraenoate compared to 15-hydroperoxyicosatetraenoate, incontrast to the wild-type, inversed substrate specificity	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.
1.13.11.31	arachidonate + O2	Homo sapiens	-	(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate	-	?
1.13.11.31	arachidonate + O2	Nomascus leucogenys	-	(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate	-	?
1.13.11.31	arachidonate + O2	Pan troglodytes	-	(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate	-	?
1.13.11.31	arachidonate + O2	Pongo pygmaeus	-	(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate	-	?
1.13.11.31	arachidonate + O2	Oryctolagus cuniculus	-	(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate	-	?
1.13.11.31	arachidonate + O2	Papio anubis	-	(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate	-	?
1.13.11.31	arachidonate + O2	Homo sapiens neanderthalensis	-	(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate	-	?
1.13.11.31	arachidonate + O2	Homo sapiens subsp. 'Denisova'	-	(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate	-	?
1.13.11.31	arachidonate + O2	Macaca mulatta	-	(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate	-	?
1.13.11.31	arachidonate + O2	Pongo abelii	-	(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate	-	?
1.13.11.31	arachidonate + O2	Pan paniscus	-	(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate	-	?
1.13.11.31	additional information	Homo sapiens	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview. The wild-type subject produces 21% 12-hydroperoxyicosatetraenoate and 79% 15-hydroperoxyicosatetraenoate	?	-	?
1.13.11.31	additional information	Nomascus leucogenys	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview. The wild-type animal produces 54% 12-hydroperoxyicosatetraenoate and 46% 15-hydroperoxyicosatetraenoate with 76% overall activity compared to the human enzyme activity	?	-	?
1.13.11.31	additional information	Pan troglodytes	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview. The wild-type animal produces 20% 12-hydroperoxyicosatetraenoate and 80% 15-hydroperoxyicosatetraenoate with 135% overall activity compared to the human enzyme activity	?	-	?
1.13.11.31	additional information	Pongo pygmaeus	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview. The wild-type animal produces 14% 12-hydroperoxyicosatetraenoate and 86% 15-hydroperoxyicosatetraenoate	?	-	?
1.13.11.31	additional information	Oryctolagus cuniculus	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview. The wild-type animal produces 3% 12-hydroperoxyicosatetraenoate and 97% 15-hydroperoxyicosatetraenoate	?	-	?
1.13.11.31	additional information	Papio anubis	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview. The wild-type animal produces 78% 12-hydroperoxyicosatetraenoate and 22% 15-hydroperoxyicosatetraenoate with 37% overall activity compared to the human enzyme activity	?	-	?
1.13.11.31	additional information	Homo sapiens neanderthalensis	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview	?	-	?
1.13.11.31	additional information	Homo sapiens subsp. 'Denisova'	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview	?	-	?
1.13.11.31	additional information	Macaca mulatta	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview	?	-	?
1.13.11.31	additional information	Pongo abelii	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview	?	-	?
1.13.11.31	additional information	Pan paniscus	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview	?	-	?
1.13.11.33	arachidonate + O2	Pongo pygmaeus	-	(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate	-	?
1.13.11.33	arachidonate + O2	Oryctolagus cuniculus	-	(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate	-	?
1.13.11.33	arachidonate + O2	Papio anubis	-	(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate	-	?
1.13.11.33	arachidonate + O2	Homo sapiens neanderthalensis	-	(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate	-	?
1.13.11.33	arachidonate + O2	Homo sapiens subsp. 'Denisova'	-	(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate	-	?
1.13.11.33	arachidonate + O2	Macaca mulatta	-	(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate	-	?
1.13.11.33	arachidonate + O2	Pongo abelii	-	(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate	-	?
1.13.11.33	arachidonate + O2	Pan paniscus	-	(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate	-	?
1.13.11.33	arachidonate + O2	Homo sapiens	-	(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate	-	?
1.13.11.33	arachidonate + O2	Nomascus leucogenys	-	(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate	-	?
1.13.11.33	arachidonate + O2	Pan troglodytes	-	(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate	-	?
1.13.11.33	additional information	Pongo pygmaeus	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview. The wild-type animal produces 14% 12-hydroperoxyicosatetraenoate and 86% 15-hydroperoxyicosatetraenoate	?	-	?
1.13.11.33	additional information	Oryctolagus cuniculus	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. The wild-type animal produces 3% 12-hydroperoxyicosatetraenoate and 97% 15-hydroperoxyicosatetraenoate	?	-	?
1.13.11.33	additional information	Papio anubis	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview. The wild-type animal produces 78% 12-hydroperoxyicosatetraenoate and 22% 15-hydroperoxyicosatetraenoate with 37% overall activity compared to the human enzyme activity	?	-	?
1.13.11.33	additional information	Homo sapiens neanderthalensis	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview	?	-	?
1.13.11.33	additional information	Homo sapiens subsp. 'Denisova'	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview	?	-	?
1.13.11.33	additional information	Macaca mulatta	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview	?	-	?
1.13.11.33	additional information	Pongo abelii	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview	?	-	?
1.13.11.33	additional information	Pan paniscus	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview	?	-	?
1.13.11.33	additional information	Homo sapiens	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview. The wild-type subject produces 21% 12-hydroperoxyicosatetraenoate and 79% 15-hydroperoxyicosatetraenoate	?	-	?
1.13.11.33	additional information	Nomascus leucogenys	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview. The wild-type animal produces 54% 12-hydroperoxyicosatetraenoate and 46% 15-hydroperoxyicosatetraenoate with 76% overall activity compared to the human enzyme activity	?	-	?
1.13.11.33	additional information	Pan troglodytes	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview. The wild-type animal produces 20% 12-hydroperoxyicosatetraenoate and 80% 15-hydroperoxyicosatetraenoate with 135% overall activity compared to the human enzyme activity	?	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.13.11.31	Homo sapiens	P16050	-	-
1.13.11.31	Homo sapiens neanderthalensis	-	-	-
1.13.11.31	Homo sapiens subsp. 'Denisova'	-	-	-
1.13.11.31	Macaca mulatta	F7EPQ4	-	-
1.13.11.31	Nomascus leucogenys	G1S6D2	-	-
1.13.11.31	Oryctolagus cuniculus	P12530	-	-
1.13.11.31	Pan paniscus	-	-	-
1.13.11.31	Pan troglodytes	H2QBX9	-	-
1.13.11.31	Papio anubis	A0A096P2G1	-	-
1.13.11.31	Pongo abelii	Q5RBE8	-	-
1.13.11.31	Pongo pygmaeus	Q5RBE8	-	-
1.13.11.33	Homo sapiens	P16050	-	-
1.13.11.33	Homo sapiens neanderthalensis	-	-	-
1.13.11.33	Homo sapiens subsp. 'Denisova'	-	-	-
1.13.11.33	Macaca mulatta	F7EPQ4	-	-
1.13.11.33	Nomascus leucogenys	G1S6D2	-	-
1.13.11.33	Oryctolagus cuniculus	P12530	-	-
1.13.11.33	Pan paniscus	-	-	-
1.13.11.33	Pan troglodytes	H2QBX9	-	-
1.13.11.33	Papio anubis	A0A096P2G1	-	-
1.13.11.33	Pongo abelii	Q5RBE8	-	-
1.13.11.33	Pongo pygmaeus	Q5RBE8	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
1.13.11.31	arachidonate + O2	-	Homo sapiens	(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate	-	?
1.13.11.31	arachidonate + O2	-	Nomascus leucogenys	(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate	-	?
1.13.11.31	arachidonate + O2	-	Pan troglodytes	(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate	-	?
1.13.11.31	arachidonate + O2	-	Pongo pygmaeus	(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate	-	?
1.13.11.31	arachidonate + O2	-	Oryctolagus cuniculus	(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate	-	?
1.13.11.31	arachidonate + O2	-	Papio anubis	(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate	-	?
1.13.11.31	arachidonate + O2	-	Homo sapiens neanderthalensis	(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate	-	?
1.13.11.31	arachidonate + O2	-	Homo sapiens subsp. 'Denisova'	(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate	-	?
1.13.11.31	arachidonate + O2	-	Macaca mulatta	(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate	-	?
1.13.11.31	arachidonate + O2	-	Pongo abelii	(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate	-	?
1.13.11.31	arachidonate + O2	-	Pan paniscus	(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate	-	?
1.13.11.31	additional information	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview. The wild-type subject produces 21% 12-hydroperoxyicosatetraenoate and 79% 15-hydroperoxyicosatetraenoate	Homo sapiens	?	-	?
1.13.11.31	additional information	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview. The wild-type animal produces 54% 12-hydroperoxyicosatetraenoate and 46% 15-hydroperoxyicosatetraenoate with 76% overall activity compared to the human enzyme activity	Nomascus leucogenys	?	-	?
1.13.11.31	additional information	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview. The wild-type animal produces 20% 12-hydroperoxyicosatetraenoate and 80% 15-hydroperoxyicosatetraenoate with 135% overall activity compared to the human enzyme activity	Pan troglodytes	?	-	?
1.13.11.31	additional information	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview. The wild-type animal produces 14% 12-hydroperoxyicosatetraenoate and 86% 15-hydroperoxyicosatetraenoate	Pongo pygmaeus	?	-	?
1.13.11.31	additional information	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview. The wild-type animal produces 3% 12-hydroperoxyicosatetraenoate and 97% 15-hydroperoxyicosatetraenoate	Oryctolagus cuniculus	?	-	?
1.13.11.31	additional information	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview. The wild-type animal produces 78% 12-hydroperoxyicosatetraenoate and 22% 15-hydroperoxyicosatetraenoate with 37% overall activity compared to the human enzyme activity	Papio anubis	?	-	?
1.13.11.31	additional information	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview	Homo sapiens neanderthalensis	?	-	?
1.13.11.31	additional information	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview	Homo sapiens subsp. 'Denisova'	?	-	?
1.13.11.31	additional information	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview	Macaca mulatta	?	-	?
1.13.11.31	additional information	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview	Pongo abelii	?	-	?
1.13.11.31	additional information	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview	Pan paniscus	?	-	?
1.13.11.31	additional information	prediction of reaction specificity of mammalian ALOX15 orthologues, and reaction specificity of ALOX15 orthologues during late primate evolution	Homo sapiens	?	-	?
1.13.11.31	additional information	prediction of reaction specificity of mammalian ALOX15 orthologues, and reaction specificity of ALOX15 orthologues during late primate evolution	Nomascus leucogenys	?	-	?
1.13.11.31	additional information	prediction of reaction specificity of mammalian ALOX15 orthologues, and reaction specificity of ALOX15 orthologues during late primate evolution	Pan troglodytes	?	-	?
1.13.11.31	additional information	prediction of reaction specificity of mammalian ALOX15 orthologues, and reaction specificity of ALOX15 orthologues during late primate evolution	Pongo pygmaeus	?	-	?
1.13.11.31	additional information	prediction of reaction specificity of mammalian ALOX15 orthologues, and reaction specificity of ALOX15 orthologues during late primate evolution	Oryctolagus cuniculus	?	-	?
1.13.11.31	additional information	prediction of reaction specificity of mammalian ALOX15 orthologues, and reaction specificity of ALOX15 orthologues during late primate evolution	Papio anubis	?	-	?
1.13.11.31	additional information	prediction of reaction specificity of mammalian ALOX15 orthologues, and reaction specificity of ALOX15 orthologues during late primate evolution	Homo sapiens neanderthalensis	?	-	?
1.13.11.31	additional information	prediction of reaction specificity of mammalian ALOX15 orthologues, and reaction specificity of ALOX15 orthologues during late primate evolution	Homo sapiens subsp. 'Denisova'	?	-	?
1.13.11.31	additional information	prediction of reaction specificity of mammalian ALOX15 orthologues, and reaction specificity of ALOX15 orthologues during late primate evolution	Macaca mulatta	?	-	?
1.13.11.31	additional information	prediction of reaction specificity of mammalian ALOX15 orthologues, and reaction specificity of ALOX15 orthologues during late primate evolution	Pongo abelii	?	-	?
1.13.11.31	additional information	prediction of reaction specificity of mammalian ALOX15 orthologues, and reaction specificity of ALOX15 orthologues during late primate evolution	Pan paniscus	?	-	?
1.13.11.33	arachidonate + O2	-	Pongo pygmaeus	(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate	-	?
1.13.11.33	arachidonate + O2	-	Oryctolagus cuniculus	(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate	-	?
1.13.11.33	arachidonate + O2	-	Papio anubis	(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate	-	?
1.13.11.33	arachidonate + O2	-	Homo sapiens neanderthalensis	(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate	-	?
1.13.11.33	arachidonate + O2	-	Homo sapiens subsp. 'Denisova'	(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate	-	?
1.13.11.33	arachidonate + O2	-	Macaca mulatta	(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate	-	?
1.13.11.33	arachidonate + O2	-	Pongo abelii	(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate	-	?
1.13.11.33	arachidonate + O2	-	Pan paniscus	(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate	-	?
1.13.11.33	arachidonate + O2	-	Homo sapiens	(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate	-	?
1.13.11.33	arachidonate + O2	-	Nomascus leucogenys	(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate	-	?
1.13.11.33	arachidonate + O2	-	Pan troglodytes	(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate	-	?
1.13.11.33	additional information	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview. The wild-type animal produces 14% 12-hydroperoxyicosatetraenoate and 86% 15-hydroperoxyicosatetraenoate	Pongo pygmaeus	?	-	?
1.13.11.33	additional information	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. The wild-type animal produces 3% 12-hydroperoxyicosatetraenoate and 97% 15-hydroperoxyicosatetraenoate	Oryctolagus cuniculus	?	-	?
1.13.11.33	additional information	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview. The wild-type animal produces 78% 12-hydroperoxyicosatetraenoate and 22% 15-hydroperoxyicosatetraenoate with 37% overall activity compared to the human enzyme activity	Papio anubis	?	-	?
1.13.11.33	additional information	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview	Homo sapiens neanderthalensis	?	-	?
1.13.11.33	additional information	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview	Homo sapiens subsp. 'Denisova'	?	-	?
1.13.11.33	additional information	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview	Macaca mulatta	?	-	?
1.13.11.33	additional information	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview	Pongo abelii	?	-	?
1.13.11.33	additional information	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview	Pan paniscus	?	-	?
1.13.11.33	additional information	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview. The wild-type subject produces 21% 12-hydroperoxyicosatetraenoate and 79% 15-hydroperoxyicosatetraenoate	Homo sapiens	?	-	?
1.13.11.33	additional information	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview. The wild-type animal produces 54% 12-hydroperoxyicosatetraenoate and 46% 15-hydroperoxyicosatetraenoate with 76% overall activity compared to the human enzyme activity	Nomascus leucogenys	?	-	?
1.13.11.33	additional information	15-lipoxygenating ALOX15 orthologs exhibit significantly higher lipoxin-synthesizing capacities than 12-lipoxygenating. Product pattern of primate ALOX15 orthologues, overview. The wild-type animal produces 20% 12-hydroperoxyicosatetraenoate and 80% 15-hydroperoxyicosatetraenoate with 135% overall activity compared to the human enzyme activity	Pan troglodytes	?	-	?
1.13.11.33	additional information	prediction of reaction specificity of mammalian ALOX15 orthologues, and reaction specificity of ALOX15 orthologues during late primate evolution	Pongo pygmaeus	?	-	?
1.13.11.33	additional information	prediction of reaction specificity of mammalian ALOX15 orthologues, and reaction specificity of ALOX15 orthologues during late primate evolution	Oryctolagus cuniculus	?	-	?
1.13.11.33	additional information	prediction of reaction specificity of mammalian ALOX15 orthologues, and reaction specificity of ALOX15 orthologues during late primate evolution	Papio anubis	?	-	?
1.13.11.33	additional information	prediction of reaction specificity of mammalian ALOX15 orthologues, and reaction specificity of ALOX15 orthologues during late primate evolution	Homo sapiens neanderthalensis	?	-	?
1.13.11.33	additional information	prediction of reaction specificity of mammalian ALOX15 orthologues, and reaction specificity of ALOX15 orthologues during late primate evolution	Homo sapiens subsp. 'Denisova'	?	-	?
1.13.11.33	additional information	prediction of reaction specificity of mammalian ALOX15 orthologues, and reaction specificity of ALOX15 orthologues during late primate evolution	Macaca mulatta	?	-	?
1.13.11.33	additional information	prediction of reaction specificity of mammalian ALOX15 orthologues, and reaction specificity of ALOX15 orthologues during late primate evolution	Pongo abelii	?	-	?
1.13.11.33	additional information	prediction of reaction specificity of mammalian ALOX15 orthologues, and reaction specificity of ALOX15 orthologues during late primate evolution	Pan paniscus	?	-	?
1.13.11.33	additional information	prediction of reaction specificity of mammalian ALOX15 orthologues, and reaction specificity of ALOX15 orthologues during late primate evolution	Homo sapiens	?	-	?
1.13.11.33	additional information	prediction of reaction specificity of mammalian ALOX15 orthologues, and reaction specificity of ALOX15 orthologues during late primate evolution	Nomascus leucogenys	?	-	?
1.13.11.33	additional information	prediction of reaction specificity of mammalian ALOX15 orthologues, and reaction specificity of ALOX15 orthologues during late primate evolution	Pan troglodytes	?	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.13.11.31	12/15-lipoxygenase	-	Homo sapiens
1.13.11.31	12/15-lipoxygenase	-	Nomascus leucogenys
1.13.11.31	12/15-lipoxygenase	-	Pan troglodytes
1.13.11.31	12/15-lipoxygenase	-	Pongo pygmaeus
1.13.11.31	12/15-lipoxygenase	-	Oryctolagus cuniculus
1.13.11.31	12/15-lipoxygenase	-	Papio anubis
1.13.11.31	12/15-lipoxygenase	-	Homo sapiens neanderthalensis
1.13.11.31	12/15-lipoxygenase	-	Homo sapiens subsp. 'Denisova'
1.13.11.31	12/15-lipoxygenase	-	Macaca mulatta
1.13.11.31	12/15-lipoxygenase	-	Pongo abelii
1.13.11.31	12/15-lipoxygenase	-	Pan paniscus
1.13.11.31	Alox15	-	Homo sapiens
1.13.11.31	Alox15	-	Nomascus leucogenys
1.13.11.31	Alox15	-	Pan troglodytes
1.13.11.31	Alox15	-	Pongo pygmaeus
1.13.11.31	Alox15	-	Oryctolagus cuniculus
1.13.11.31	Alox15	-	Papio anubis
1.13.11.31	Alox15	-	Homo sapiens neanderthalensis
1.13.11.31	Alox15	-	Homo sapiens subsp. 'Denisova'
1.13.11.31	Alox15	-	Macaca mulatta
1.13.11.31	Alox15	-	Pongo abelii
1.13.11.31	Alox15	-	Pan paniscus
1.13.11.33	12/15-lipoxygenase	-	Pongo pygmaeus
1.13.11.33	12/15-lipoxygenase	-	Oryctolagus cuniculus
1.13.11.33	12/15-lipoxygenase	-	Papio anubis
1.13.11.33	12/15-lipoxygenase	-	Homo sapiens neanderthalensis
1.13.11.33	12/15-lipoxygenase	-	Homo sapiens subsp. 'Denisova'
1.13.11.33	12/15-lipoxygenase	-	Macaca mulatta
1.13.11.33	12/15-lipoxygenase	-	Pongo abelii
1.13.11.33	12/15-lipoxygenase	-	Pan paniscus
1.13.11.33	12/15-lipoxygenase	-	Homo sapiens
1.13.11.33	12/15-lipoxygenase	-	Nomascus leucogenys
1.13.11.33	12/15-lipoxygenase	-	Pan troglodytes
1.13.11.33	Alox15	-	Pongo pygmaeus
1.13.11.33	Alox15	-	Oryctolagus cuniculus
1.13.11.33	Alox15	-	Papio anubis
1.13.11.33	Alox15	-	Homo sapiens neanderthalensis
1.13.11.33	Alox15	-	Homo sapiens subsp. 'Denisova'
1.13.11.33	Alox15	-	Macaca mulatta
1.13.11.33	Alox15	-	Pongo abelii
1.13.11.33	Alox15	-	Pan paniscus
1.13.11.33	Alox15	-	Homo sapiens
1.13.11.33	Alox15	-	Nomascus leucogenys
1.13.11.33	Alox15	-	Pan troglodytes

General Information

EC Number	General Information	Comment	Organism
1.13.11.31	evolution	mammals (mice, rats, pigs) express 12-lipoxygenating ALOX15 orthologues. 15-lipoxygenating isoforms are found in primates (orangutans, humans), suggesting an evolution of ALOX15 specificity. Other primates (baboons, rhesus monkeys) express 12-lipoxygenating enzymes. Gibbons, which are flanked in evolution by rhesus monkeys (12-lipoxygenating ALOX15) and orangutans (15-lipoxygenating ALOX15), express an ALOX15 ortholog with pronounced dual specificity, an evolution of ALOX15 specificity, which is aimed at optimizing the biosynthetic capacity for antiinflammatory and proresolving lipoxins. Phylogenetic analysis	Homo sapiens
1.13.11.31	evolution	mammals (mice, rats, pigs) express 12-lipoxygenating ALOX15 orthologues. 15-lipoxygenating isoforms are found in primates (orangutans, humans), suggesting an evolution of ALOX15 specificity. Other primates (baboons, rhesus monkeys) express 12-lipoxygenating enzymes. Gibbons, which are flanked in evolution by rhesus monkeys (12-lipoxygenating ALOX15) and orangutans (15-lipoxygenating ALOX15), express an ALOX15 ortholog with pronounced dual specificity, an evolution of ALOX15 specificity, which is aimed at optimizing the biosynthetic capacity for antiinflammatory and proresolving lipoxins. Phylogenetic analysis	Nomascus leucogenys
1.13.11.31	evolution	mammals (mice, rats, pigs) express 12-lipoxygenating ALOX15 orthologues. 15-lipoxygenating isoforms are found in primates (orangutans, humans), suggesting an evolution of ALOX15 specificity. Other primates (baboons, rhesus monkeys) express 12-lipoxygenating enzymes. Gibbons, which are flanked in evolution by rhesus monkeys (12-lipoxygenating ALOX15) and orangutans (15-lipoxygenating ALOX15), express an ALOX15 ortholog with pronounced dual specificity, an evolution of ALOX15 specificity, which is aimed at optimizing the biosynthetic capacity for antiinflammatory and proresolving lipoxins. Phylogenetic analysis	Pan troglodytes
1.13.11.31	evolution	mammals (mice, rats, pigs) express 12-lipoxygenating ALOX15 orthologues. 15-lipoxygenating isoforms are found in primates (orangutans, humans), suggesting an evolution of ALOX15 specificity. Other primates (baboons, rhesus monkeys) express 12-lipoxygenating enzymes. Gibbons, which are flanked in evolution by rhesus monkeys (12-lipoxygenating ALOX15) and orangutans (15-lipoxygenating ALOX15), express an ALOX15 ortholog with pronounced dual specificity, an evolution of ALOX15 specificity, which is aimed at optimizing the biosynthetic capacity for antiinflammatory and proresolving lipoxins. Phylogenetic analysis	Pongo pygmaeus
1.13.11.31	evolution	mammals (mice, rats, pigs) express 12-lipoxygenating ALOX15 orthologues. 15-lipoxygenating isoforms are found in primates (orangutans, humans), suggesting an evolution of ALOX15 specificity. Other primates (baboons, rhesus monkeys) express 12-lipoxygenating enzymes. Gibbons, which are flanked in evolution by rhesus monkeys (12-lipoxygenating ALOX15) and orangutans (15-lipoxygenating ALOX15), express an ALOX15 ortholog with pronounced dual specificity, an evolution of ALOX15 specificity, which is aimed at optimizing the biosynthetic capacity for antiinflammatory and proresolving lipoxins. Phylogenetic analysis	Oryctolagus cuniculus
1.13.11.31	evolution	mammals (mice, rats, pigs) express 12-lipoxygenating ALOX15 orthologues. 15-lipoxygenating isoforms are found in primates (orangutans, humans), suggesting an evolution of ALOX15 specificity. Other primates (baboons, rhesus monkeys) express 12-lipoxygenating enzymes. Gibbons, which are flanked in evolution by rhesus monkeys (12-lipoxygenating ALOX15) and orangutans (15-lipoxygenating ALOX15), express an ALOX15 ortholog with pronounced dual specificity, an evolution of ALOX15 specificity, which is aimed at optimizing the biosynthetic capacity for antiinflammatory and proresolving lipoxins. Phylogenetic analysis	Papio anubis
1.13.11.31	evolution	mammals (mice, rats, pigs) express 12-lipoxygenating ALOX15 orthologues. 15-lipoxygenating isoforms are found in primates (orangutans, humans), suggesting an evolution of ALOX15 specificity. Other primates (baboons, rhesus monkeys) express 12-lipoxygenating enzymes. Gibbons, which are flanked in evolution by rhesus monkeys (12-lipoxygenating ALOX15) and orangutans (15-lipoxygenating ALOX15), express an ALOX15 ortholog with pronounced dual specificity, an evolution of ALOX15 specificity, which is aimed at optimizing the biosynthetic capacity for antiinflammatory and proresolving lipoxins. Phylogenetic analysis	Homo sapiens neanderthalensis
1.13.11.31	evolution	mammals (mice, rats, pigs) express 12-lipoxygenating ALOX15 orthologues. 15-lipoxygenating isoforms are found in primates (orangutans, humans), suggesting an evolution of ALOX15 specificity. Other primates (baboons, rhesus monkeys) express 12-lipoxygenating enzymes. Gibbons, which are flanked in evolution by rhesus monkeys (12-lipoxygenating ALOX15) and orangutans (15-lipoxygenating ALOX15), express an ALOX15 ortholog with pronounced dual specificity, an evolution of ALOX15 specificity, which is aimed at optimizing the biosynthetic capacity for antiinflammatory and proresolving lipoxins. Phylogenetic analysis	Homo sapiens subsp. 'Denisova'
1.13.11.31	evolution	mammals (mice, rats, pigs) express 12-lipoxygenating ALOX15 orthologues. 15-lipoxygenating isoforms are found in primates (orangutans, humans), suggesting an evolution of ALOX15 specificity. Other primates (baboons, rhesus monkeys) express 12-lipoxygenating enzymes. Gibbons, which are flanked in evolution by rhesus monkeys (12-lipoxygenating ALOX15) and orangutans (15-lipoxygenating ALOX15), express an ALOX15 ortholog with pronounced dual specificity, an evolution of ALOX15 specificity, which is aimed at optimizing the biosynthetic capacity for antiinflammatory and proresolving lipoxins. Phylogenetic analysis	Macaca mulatta
1.13.11.31	evolution	mammals (mice, rats, pigs) express 12-lipoxygenating ALOX15 orthologues. 15-lipoxygenating isoforms are found in primates (orangutans, humans), suggesting an evolution of ALOX15 specificity. Other primates (baboons, rhesus monkeys) express 12-lipoxygenating enzymes. Gibbons, which are flanked in evolution by rhesus monkeys (12-lipoxygenating ALOX15) and orangutans (15-lipoxygenating ALOX15), express an ALOX15 ortholog with pronounced dual specificity, an evolution of ALOX15 specificity, which is aimed at optimizing the biosynthetic capacity for antiinflammatory and proresolving lipoxins. Phylogenetic analysis	Pongo abelii
1.13.11.31	evolution	mammals (mice, rats, pigs) express 12-lipoxygenating ALOX15 orthologues. 15-lipoxygenating isoforms are found in primates (orangutans, humans), suggesting an evolution of ALOX15 specificity. Other primates (baboons, rhesus monkeys) express 12-lipoxygenating enzymes. Gibbons, which are flanked in evolution by rhesus monkeys (12-lipoxygenating ALOX15) and orangutans (15-lipoxygenating ALOX15), express an ALOX15 ortholog with pronounced dual specificity, an evolution of ALOX15 specificity, which is aimed at optimizing the biosynthetic capacity for antiinflammatory and proresolving lipoxins. Phylogenetic analysis	Pan paniscus
1.13.11.31	additional information	molecular dynamics simulations and quantum mechanics/molecular mechanics calculations	Homo sapiens
1.13.11.31	additional information	molecular dynamics simulations and quantum mechanics/molecular mechanics calculations	Nomascus leucogenys
1.13.11.31	additional information	molecular dynamics simulations and quantum mechanics/molecular mechanics calculations	Pan troglodytes
1.13.11.31	additional information	molecular dynamics simulations and quantum mechanics/molecular mechanics calculations	Pongo pygmaeus
1.13.11.31	additional information	molecular dynamics simulations and quantum mechanics/molecular mechanics calculations	Oryctolagus cuniculus
1.13.11.31	additional information	molecular dynamics simulations and quantum mechanics/molecular mechanics calculations	Papio anubis
1.13.11.31	additional information	molecular dynamics simulations and quantum mechanics/molecular mechanics calculations	Homo sapiens neanderthalensis
1.13.11.31	additional information	molecular dynamics simulations and quantum mechanics/molecular mechanics calculations	Homo sapiens subsp. 'Denisova'
1.13.11.31	additional information	molecular dynamics simulations and quantum mechanics/molecular mechanics calculations	Macaca mulatta
1.13.11.31	additional information	molecular dynamics simulations and quantum mechanics/molecular mechanics calculations	Pongo abelii
1.13.11.31	additional information	molecular dynamics simulations and quantum mechanics/molecular mechanics calculations	Pan paniscus
1.13.11.31	physiological function	ALOX15-encoded 12/15-lipoxygenase orthologs are implicated in maturational degradation of intracellular organelles and in the biosynthesis of antiinflammatory and proresolving eicosanoids	Homo sapiens
1.13.11.31	physiological function	ALOX15-encoded 12/15-lipoxygenase orthologs are implicated in maturational degradation of intracellular organelles and in the biosynthesis of antiinflammatory and proresolving eicosanoids	Nomascus leucogenys
1.13.11.31	physiological function	ALOX15-encoded 12/15-lipoxygenase orthologs are implicated in maturational degradation of intracellular organelles and in the biosynthesis of antiinflammatory and proresolving eicosanoids	Pan troglodytes
1.13.11.31	physiological function	ALOX15-encoded 12/15-lipoxygenase orthologs are implicated in maturational degradation of intracellular organelles and in the biosynthesis of antiinflammatory and proresolving eicosanoids	Pongo pygmaeus
1.13.11.31	physiological function	ALOX15-encoded 12/15-lipoxygenase orthologs are implicated in maturational degradation of intracellular organelles and in the biosynthesis of antiinflammatory and proresolving eicosanoids	Oryctolagus cuniculus
1.13.11.31	physiological function	ALOX15-encoded 12/15-lipoxygenase orthologs are implicated in maturational degradation of intracellular organelles and in the biosynthesis of antiinflammatory and proresolving eicosanoids	Papio anubis
1.13.11.31	physiological function	ALOX15-encoded 12/15-lipoxygenase orthologs are implicated in maturational degradation of intracellular organelles and in the biosynthesis of antiinflammatory and proresolving eicosanoids	Homo sapiens neanderthalensis
1.13.11.31	physiological function	ALOX15-encoded 12/15-lipoxygenase orthologs are implicated in maturational degradation of intracellular organelles and in the biosynthesis of antiinflammatory and proresolving eicosanoids	Homo sapiens subsp. 'Denisova'
1.13.11.31	physiological function	ALOX15-encoded 12/15-lipoxygenase orthologs are implicated in maturational degradation of intracellular organelles and in the biosynthesis of antiinflammatory and proresolving eicosanoids	Macaca mulatta
1.13.11.31	physiological function	ALOX15-encoded 12/15-lipoxygenase orthologs are implicated in maturational degradation of intracellular organelles and in the biosynthesis of antiinflammatory and proresolving eicosanoids	Pongo abelii
1.13.11.31	physiological function	ALOX15-encoded 12/15-lipoxygenase orthologs are implicated in maturational degradation of intracellular organelles and in the biosynthesis of antiinflammatory and proresolving eicosanoids	Pan paniscus
1.13.11.33	evolution	mammals (mice, rats, pigs) express 12-lipoxygenating ALOX15 orthologues. 15-lipoxygenating isoforms are found in primates (orangutans, humans), suggesting an evolution of ALOX15 specificity. Other primates (baboons, rhesus monkeys) express 12-lipoxygenating enzymes. Gibbons, which are flanked in evolution by rhesus monkeys (12-lipoxygenating ALOX15) and orangutans (15-lipoxygenating ALOX15), express an ALOX15 ortholog with pronounced dual specificity, an evolution of ALOX15 specificity, which is aimed at optimizing the biosynthetic capacity for antiinflammatory and proresolving lipoxins. Phylogenetic analysis	Pongo pygmaeus
1.13.11.33	evolution	mammals (mice, rats, pigs) express 12-lipoxygenating ALOX15 orthologues. 15-lipoxygenating isoforms are found in primates (orangutans, humans), suggesting an evolution of ALOX15 specificity. Other primates (baboons, rhesus monkeys) express 12-lipoxygenating enzymes. Gibbons, which are flanked in evolution by rhesus monkeys (12-lipoxygenating ALOX15) and orangutans (15-lipoxygenating ALOX15), express an ALOX15 ortholog with pronounced dual specificity, an evolution of ALOX15 specificity, which is aimed at optimizing the biosynthetic capacity for antiinflammatory and proresolving lipoxins. Phylogenetic analysis	Oryctolagus cuniculus
1.13.11.33	evolution	mammals (mice, rats, pigs) express 12-lipoxygenating ALOX15 orthologues. 15-lipoxygenating isoforms are found in primates (orangutans, humans), suggesting an evolution of ALOX15 specificity. Other primates (baboons, rhesus monkeys) express 12-lipoxygenating enzymes. Gibbons, which are flanked in evolution by rhesus monkeys (12-lipoxygenating ALOX15) and orangutans (15-lipoxygenating ALOX15), express an ALOX15 ortholog with pronounced dual specificity, an evolution of ALOX15 specificity, which is aimed at optimizing the biosynthetic capacity for antiinflammatory and proresolving lipoxins. Phylogenetic analysis	Papio anubis
1.13.11.33	evolution	mammals (mice, rats, pigs) express 12-lipoxygenating ALOX15 orthologues. 15-lipoxygenating isoforms are found in primates (orangutans, humans), suggesting an evolution of ALOX15 specificity. Other primates (baboons, rhesus monkeys) express 12-lipoxygenating enzymes. Gibbons, which are flanked in evolution by rhesus monkeys (12-lipoxygenating ALOX15) and orangutans (15-lipoxygenating ALOX15), express an ALOX15 ortholog with pronounced dual specificity, an evolution of ALOX15 specificity, which is aimed at optimizing the biosynthetic capacity for antiinflammatory and proresolving lipoxins. Phylogenetic analysis	Homo sapiens neanderthalensis
1.13.11.33	evolution	mammals (mice, rats, pigs) express 12-lipoxygenating ALOX15 orthologues. 15-lipoxygenating isoforms are found in primates (orangutans, humans), suggesting an evolution of ALOX15 specificity. Other primates (baboons, rhesus monkeys) express 12-lipoxygenating enzymes. Gibbons, which are flanked in evolution by rhesus monkeys (12-lipoxygenating ALOX15) and orangutans (15-lipoxygenating ALOX15), express an ALOX15 ortholog with pronounced dual specificity, an evolution of ALOX15 specificity, which is aimed at optimizing the biosynthetic capacity for antiinflammatory and proresolving lipoxins. Phylogenetic analysis	Homo sapiens subsp. 'Denisova'
1.13.11.33	evolution	mammals (mice, rats, pigs) express 12-lipoxygenating ALOX15 orthologues. 15-lipoxygenating isoforms are found in primates (orangutans, humans), suggesting an evolution of ALOX15 specificity. Other primates (baboons, rhesus monkeys) express 12-lipoxygenating enzymes. Gibbons, which are flanked in evolution by rhesus monkeys (12-lipoxygenating ALOX15) and orangutans (15-lipoxygenating ALOX15), express an ALOX15 ortholog with pronounced dual specificity, an evolution of ALOX15 specificity, which is aimed at optimizing the biosynthetic capacity for antiinflammatory and proresolving lipoxins. Phylogenetic analysis	Macaca mulatta
1.13.11.33	evolution	mammals (mice, rats, pigs) express 12-lipoxygenating ALOX15 orthologues. 15-lipoxygenating isoforms are found in primates (orangutans, humans), suggesting an evolution of ALOX15 specificity. Other primates (baboons, rhesus monkeys) express 12-lipoxygenating enzymes. Gibbons, which are flanked in evolution by rhesus monkeys (12-lipoxygenating ALOX15) and orangutans (15-lipoxygenating ALOX15), express an ALOX15 ortholog with pronounced dual specificity, an evolution of ALOX15 specificity, which is aimed at optimizing the biosynthetic capacity for antiinflammatory and proresolving lipoxins. Phylogenetic analysis	Pongo abelii
1.13.11.33	evolution	mammals (mice, rats, pigs) express 12-lipoxygenating ALOX15 orthologues. 15-lipoxygenating isoforms are found in primates (orangutans, humans), suggesting an evolution of ALOX15 specificity. Other primates (baboons, rhesus monkeys) express 12-lipoxygenating enzymes. Gibbons, which are flanked in evolution by rhesus monkeys (12-lipoxygenating ALOX15) and orangutans (15-lipoxygenating ALOX15), express an ALOX15 ortholog with pronounced dual specificity, an evolution of ALOX15 specificity, which is aimed at optimizing the biosynthetic capacity for antiinflammatory and proresolving lipoxins. Phylogenetic analysis	Pan paniscus
1.13.11.33	evolution	mammals (mice, rats, pigs) express 12-lipoxygenating ALOX15 orthologues. 15-lipoxygenating isoforms are found in primates (orangutans, humans), suggesting an evolution of ALOX15 specificity. Other primates (baboons, rhesus monkeys) express 12-lipoxygenating enzymes. Gibbons, which are flanked in evolution by rhesus monkeys (12-lipoxygenating ALOX15) and orangutans (15-lipoxygenating ALOX15), express an ALOX15 ortholog with pronounced dual specificity, an evolution of ALOX15 specificity, which is aimed at optimizing the biosynthetic capacity for antiinflammatory and proresolving lipoxins. Phylogenetic analysis	Homo sapiens
1.13.11.33	evolution	mammals (mice, rats, pigs) express 12-lipoxygenating ALOX15 orthologues. 15-lipoxygenating isoforms are found in primates (orangutans, humans), suggesting an evolution of ALOX15 specificity. Other primates (baboons, rhesus monkeys) express 12-lipoxygenating enzymes. Gibbons, which are flanked in evolution by rhesus monkeys (12-lipoxygenating ALOX15) and orangutans (15-lipoxygenating ALOX15), express an ALOX15 ortholog with pronounced dual specificity, an evolution of ALOX15 specificity, which is aimed at optimizing the biosynthetic capacity for antiinflammatory and proresolving lipoxins. Phylogenetic analysis	Nomascus leucogenys
1.13.11.33	evolution	mammals (mice, rats, pigs) express 12-lipoxygenating ALOX15 orthologues. 15-lipoxygenating isoforms are found in primates (orangutans, humans), suggesting an evolution of ALOX15 specificity. Other primates (baboons, rhesus monkeys) express 12-lipoxygenating enzymes. Gibbons, which are flanked in evolution by rhesus monkeys (12-lipoxygenating ALOX15) and orangutans (15-lipoxygenating ALOX15), express an ALOX15 ortholog with pronounced dual specificity, an evolution of ALOX15 specificity, which is aimed at optimizing the biosynthetic capacity for antiinflammatory and proresolving lipoxins. Phylogenetic analysis	Pan troglodytes
1.13.11.33	additional information	molecular dynamics simulations and quantum mechanics/molecular mechanics calculations	Pongo pygmaeus
1.13.11.33	additional information	molecular dynamics simulations and quantum mechanics/molecular mechanics calculations	Oryctolagus cuniculus
1.13.11.33	additional information	molecular dynamics simulations and quantum mechanics/molecular mechanics calculations	Papio anubis
1.13.11.33	additional information	molecular dynamics simulations and quantum mechanics/molecular mechanics calculations	Homo sapiens neanderthalensis
1.13.11.33	additional information	molecular dynamics simulations and quantum mechanics/molecular mechanics calculations	Homo sapiens subsp. 'Denisova'
1.13.11.33	additional information	molecular dynamics simulations and quantum mechanics/molecular mechanics calculations	Macaca mulatta
1.13.11.33	additional information	molecular dynamics simulations and quantum mechanics/molecular mechanics calculations	Pongo abelii
1.13.11.33	additional information	molecular dynamics simulations and quantum mechanics/molecular mechanics calculations	Pan paniscus
1.13.11.33	additional information	molecular dynamics simulations and quantum mechanics/molecular mechanics calculations	Homo sapiens
1.13.11.33	additional information	molecular dynamics simulations and quantum mechanics/molecular mechanics calculations	Nomascus leucogenys
1.13.11.33	additional information	molecular dynamics simulations and quantum mechanics/molecular mechanics calculations	Pan troglodytes
1.13.11.33	physiological function	ALOX15-encoded 12/15-lipoxygenase orthologs are implicated in maturational degradation of intracellular organelles and in the biosynthesis of antiinflammatory and proresolving eicosanoids	Pongo pygmaeus
1.13.11.33	physiological function	ALOX15-encoded 12/15-lipoxygenase orthologs are implicated in maturational degradation of intracellular organelles and in the biosynthesis of antiinflammatory and proresolving eicosanoids	Oryctolagus cuniculus
1.13.11.33	physiological function	ALOX15-encoded 12/15-lipoxygenase orthologs are implicated in maturational degradation of intracellular organelles and in the biosynthesis of antiinflammatory and proresolving eicosanoids	Papio anubis
1.13.11.33	physiological function	ALOX15-encoded 12/15-lipoxygenase orthologs are implicated in maturational degradation of intracellular organelles and in the biosynthesis of antiinflammatory and proresolving eicosanoids	Homo sapiens neanderthalensis
1.13.11.33	physiological function	ALOX15-encoded 12/15-lipoxygenase orthologs are implicated in maturational degradation of intracellular organelles and in the biosynthesis of antiinflammatory and proresolving eicosanoids	Homo sapiens subsp. 'Denisova'
1.13.11.33	physiological function	ALOX15-encoded 12/15-lipoxygenase orthologs are implicated in maturational degradation of intracellular organelles and in the biosynthesis of antiinflammatory and proresolving eicosanoids	Macaca mulatta
1.13.11.33	physiological function	ALOX15-encoded 12/15-lipoxygenase orthologs are implicated in maturational degradation of intracellular organelles and in the biosynthesis of antiinflammatory and proresolving eicosanoids	Pongo abelii
1.13.11.33	physiological function	ALOX15-encoded 12/15-lipoxygenase orthologs are implicated in maturational degradation of intracellular organelles and in the biosynthesis of antiinflammatory and proresolving eicosanoids	Pan paniscus
1.13.11.33	physiological function	ALOX15-encoded 12/15-lipoxygenase orthologs are implicated in maturational degradation of intracellular organelles and in the biosynthesis of antiinflammatory and proresolving eicosanoids	Homo sapiens
1.13.11.33	physiological function	ALOX15-encoded 12/15-lipoxygenase orthologs are implicated in maturational degradation of intracellular organelles and in the biosynthesis of antiinflammatory and proresolving eicosanoids	Nomascus leucogenys
1.13.11.33	physiological function	ALOX15-encoded 12/15-lipoxygenase orthologs are implicated in maturational degradation of intracellular organelles and in the biosynthesis of antiinflammatory and proresolving eicosanoids	Pan troglodytes