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Literature summary extracted from

  • Zhang, X.; Carter, M.; Vetting, M.; Francisco, B.; Zhao, S.; Al-Obaidi, N.; Solbiati, J.; Thiaville, J.; Crecy-Lagard, V.; Jacobson, M.; Almo, S.; Gerlt, J.
    Assignment of function to a domain of unknown function DUF1537 is a new kinase family in catabolic pathways for acid sugars (2016), Proc. Natl. Acad. Sci. USA, 113, E4161-E4169 .
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.219 0.12
-
 D-threonate pH 8.0, 25°C Cupriavidus necator
2.7.1.219 0.29
-
 D-threonate pH 8.0, 25°C Salmonella enterica subsp. enterica serovar Typhimurium
2.7.1.219 3.8
-
 4-hydroxy-L-threonine pH 8.0, 25°C Salmonella enterica subsp. enterica serovar Typhimurium
2.7.1.219 86
-
 4-hydroxy-L-threonine pH 8.0, 25°C Cupriavidus necator
2.7.1.220 0.081
-
 D-erythronate pH 8.0, 25°C Heliomicrobium modesticaldum
2.7.1.220 3.2
-
 D-threonate pH 8.0, 25°C Heliomicrobium modesticaldum
2.7.1.220 44
-
 4-hydroxy-L-threonine pH 8.0, 25°C Heliomicrobium modesticaldum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.104 3-oxo-tetronate 4-phosphate Pectobacterium atrosepticum
-
 dihydroxyacetone phosphate + CO2
-
 ?
4.1.1.104 3-oxo-tetronate 4-phosphate Haemophilus influenzae
-
 dihydroxyacetone phosphate + CO2
-
 ?
4.1.1.104 3-oxo-tetronate 4-phosphate Cupriavidus necator
-
 dihydroxyacetone phosphate + CO2
-
 ?
4.1.1.104 3-oxo-tetronate 4-phosphate Escherichia coli
-
 dihydroxyacetone phosphate + CO2
-
 ?
4.1.1.104 3-oxo-tetronate 4-phosphate Pectobacterium atrosepticum ATCC BAA-672
-
 dihydroxyacetone phosphate + CO2
-
 ?
4.1.1.104 3-oxo-tetronate 4-phosphate Escherichia coli ATCC 700928
-
 dihydroxyacetone phosphate + CO2
-
 ?
4.1.1.104 3-oxo-tetronate 4-phosphate Haemophilus influenzae ATCC 51907
-
 dihydroxyacetone phosphate + CO2
-
 ?
4.1.1.104 3-oxo-tetronate 4-phosphate Cupriavidus necator ATCC 17699
-
 dihydroxyacetone phosphate + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.219 Cupriavidus necator Q0K4F6 member of the DUF1537 family, participates in catabolic pathways for four-carbon acid sugars
-
2.7.1.219 Cupriavidus necator DSM 428 Q0K4F6 member of the DUF1537 family, participates in catabolic pathways for four-carbon acid sugars
-
2.7.1.219 Salmonella enterica subsp. enterica serovar Typhimurium Q8ZRS5 member of the DUF1537 family, participates in catabolic pathways for four-carbon acid sugars
-
2.7.1.219 Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 Q8ZRS5 member of the DUF1537 family, participates in catabolic pathways for four-carbon acid sugars
-
2.7.1.220 Heliomicrobium modesticaldum B0TBI9
-
-
2.7.1.220 Heliomicrobium modesticaldum ATCC 51547 B0TBI9
-
-
4.1.1.104 Cupriavidus necator Q0KBC9
-
-
4.1.1.104 Cupriavidus necator ATCC 17699 Q0KBC9
-
-
4.1.1.104 Escherichia coli A0A0H2VA12
-
-
4.1.1.104 Escherichia coli ATCC 700928 A0A0H2VA12
-
-
4.1.1.104 Haemophilus influenzae Q57199
-
-
4.1.1.104 Haemophilus influenzae ATCC 51907 Q57199
-
-
4.1.1.104 Pectobacterium atrosepticum Q6CZ24
-
-
4.1.1.104 Pectobacterium atrosepticum ATCC BAA-672 Q6CZ24
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.219 ATP + 4-hydroxy-L-threonine
-
 Salmonella enterica subsp. enterica serovar Typhimurium ADP + 4-phospho-L-threonine
-
 ?
2.7.1.219 ATP + 4-hydroxy-L-threonine
-
 Cupriavidus necator ADP + 4-phospho-L-threonine
-
 ?
2.7.1.219 ATP + 4-hydroxy-L-threonine
-
 Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 ADP + 4-phospho-L-threonine
-
 ?
2.7.1.219 ATP + 4-hydroxy-L-threonine
-
 Cupriavidus necator DSM 428 ADP + 4-phospho-L-threonine
-
 ?
2.7.1.219 ATP + D-threonate
-
 Salmonella enterica subsp. enterica serovar Typhimurium ADP + 4-phospho-D-threonate
-
 ?
2.7.1.219 ATP + D-threonate
-
 Cupriavidus necator ADP + 4-phospho-D-threonate
-
 ?
2.7.1.219 ATP + D-threonate
-
 Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 ADP + 4-phospho-D-threonate
-
 ?
2.7.1.219 ATP + D-threonate
-
 Cupriavidus necator DSM 428 ADP + 4-phospho-D-threonate
-
 ?
2.7.1.220 ATP + 4-hydroxy-L-threonine
-
 Heliomicrobium modesticaldum ADP + 4-phospho-L-threonine
-
 ?
2.7.1.220 ATP + 4-hydroxy-L-threonine
-
 Heliomicrobium modesticaldum ATCC 51547 ADP + 4-phospho-L-threonine
-
 ?
2.7.1.220 ATP + D-erythronate
-
 Heliomicrobium modesticaldum ADP + 4-phospho-D-erythronate
-
 ?
2.7.1.220 ATP + D-erythronate
-
 Heliomicrobium modesticaldum ATCC 51547 ADP + 4-phospho-D-erythronate
-
 ?
2.7.1.220 ATP + D-threonate
-
 Heliomicrobium modesticaldum ADP + 4-phospho-D-threonate
-
 ?
2.7.1.220 ATP + D-threonate
-
 Heliomicrobium modesticaldum ATCC 51547 ADP + 4-phospho-D-threonate
-
 ?
4.1.1.104 3-oxo-tetronate 4-phosphate
-
 Pectobacterium atrosepticum dihydroxyacetone phosphate + CO2
-
 ?
4.1.1.104 3-oxo-tetronate 4-phosphate
-
 Haemophilus influenzae dihydroxyacetone phosphate + CO2
-
 ?
4.1.1.104 3-oxo-tetronate 4-phosphate
-
 Cupriavidus necator dihydroxyacetone phosphate + CO2
-
 ?
4.1.1.104 3-oxo-tetronate 4-phosphate
-
 Escherichia coli dihydroxyacetone phosphate + CO2
-
 ?
4.1.1.104 3-oxo-tetronate 4-phosphate
-
 Pectobacterium atrosepticum ATCC BAA-672 dihydroxyacetone phosphate + CO2
-
 ?
4.1.1.104 3-oxo-tetronate 4-phosphate
-
 Escherichia coli ATCC 700928 dihydroxyacetone phosphate + CO2
-
 ?
4.1.1.104 3-oxo-tetronate 4-phosphate
-
 Haemophilus influenzae ATCC 51907 dihydroxyacetone phosphate + CO2
-
 ?
4.1.1.104 3-oxo-tetronate 4-phosphate
-
 Cupriavidus necator ATCC 17699 dihydroxyacetone phosphate + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.219 D-threonate kinase
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.7.1.219 D-threonate kinase
-
 Cupriavidus necator
2.7.1.219 dtnK
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.7.1.219 dtnK
-
 Cupriavidus necator
2.7.1.220 denK
-
 Heliomicrobium modesticaldum
4.1.1.104 3-oxo-tetronate 4-phosphate decarboxylase
-
 Pectobacterium atrosepticum
4.1.1.104 3-oxo-tetronate 4-phosphate decarboxylase
-
 Haemophilus influenzae
4.1.1.104 3-oxo-tetronate 4-phosphate decarboxylase
-
 Cupriavidus necator
4.1.1.104 3-oxo-tetronate 4-phosphate decarboxylase
-
 Escherichia coli
4.1.1.104 otnC
-
 Pectobacterium atrosepticum
4.1.1.104 otnC
-
 Haemophilus influenzae
4.1.1.104 otnC
-
 Cupriavidus necator
4.1.1.104 otnC
-
 Escherichia coli

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.7.1.219 4
-
 4-hydroxy-L-threonine pH 8.0, 25°C Salmonella enterica subsp. enterica serovar Typhimurium
2.7.1.219 22
-
 D-threonate pH 8.0, 25°C Salmonella enterica subsp. enterica serovar Typhimurium
2.7.1.219 27
-
 4-hydroxy-L-threonine pH 8.0, 25°C Cupriavidus necator
2.7.1.219 45
-
 D-threonate pH 8.0, 25°C Cupriavidus necator
2.7.1.220 12
-
 D-threonate pH 8.0, 25°C Heliomicrobium modesticaldum
2.7.1.220 16
-
 D-erythronate pH 8.0, 25°C Heliomicrobium modesticaldum
2.7.1.220 41
-
 4-hydroxy-L-threonine pH 8.0, 25°C Heliomicrobium modesticaldum

General Information

EC Number General Information Comment Organism
2.7.1.219 physiological function a gene deletion strain is unable to use D-threonate as a carbon source Salmonella enterica subsp. enterica serovar Typhimurium
2.7.1.219 physiological function a gene deletion strain is unable to use D-threonate as a carbon source Cupriavidus necator

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
2.7.1.219 0.31
-
 4-hydroxy-L-threonine pH 8.0, 25°C Cupriavidus necator
2.7.1.219 1.1
-
 4-hydroxy-L-threonine pH 8.0, 25°C Salmonella enterica subsp. enterica serovar Typhimurium
2.7.1.219 75
-
 D-threonate pH 8.0, 25°C Salmonella enterica subsp. enterica serovar Typhimurium
2.7.1.219 380
-
 D-threonate pH 8.0, 25°C Cupriavidus necator
2.7.1.220 0.94
-
 4-hydroxy-L-threonine pH 8.0, 25°C Heliomicrobium modesticaldum
2.7.1.220 3.8
-
 D-threonate pH 8.0, 25°C Heliomicrobium modesticaldum
2.7.1.220 190
-
 D-erythronate pH 8.0, 25°C Heliomicrobium modesticaldum
4.1.1.104 0.21
-
 3-oxo-tetronate 4-phosphate pH and temperature not specified in the publication Cupriavidus necator
4.1.1.104 0.4
-
 3-oxo-tetronate 4-phosphate pH and temperature not specified in the publication Escherichia coli
4.1.1.104 2.3
-
 3-oxo-tetronate 4-phosphate pH and temperature not specified in the publication Pectobacterium atrosepticum
4.1.1.104 13
-
 3-oxo-tetronate 4-phosphate pH and temperature not specified in the publication Haemophilus influenzae