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Literature summary extracted from

  • Wan, P.; Yuan, S.; Tang, Y.; Li, K.; Yang, L.; Fu, Q.; Li, G.
    Pathways of amino acid degradation in Nilaparvata lugens (Stal) with special reference to lysine-ketoglutarate reductase/saccharopine dehydrogenase (LKR/SDH) (2015), PLoS ONE, 10, e0127789 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.5.1.8 gene nllkr/sdh, DNA and amino acid sequence determination and analysis, phylogenic analysis, quantitative real-time PCR expression analysis Nilaparvata lugens
1.5.1.9 gene nllkr/sdh, DNA and amino acid sequence determination and analysis, phylogenic analysis, quantitative real-time PCR expression analysis Nilaparvata lugens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.1.8 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O Nilaparvata lugens
-
 L-lysine + 2-oxoglutarate + NADH + H+
-
 r
1.5.1.9 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O Nilaparvata lugens
-
 L-glutamate + (S)-2-amino-6-oxohexanoate + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.8 Nilaparvata lugens A0A089MUZ6
-
-
1.5.1.9 Nilaparvata lugens A0A089MUZ6
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.8 adult
-
 Nilaparvata lugens
-
1.5.1.8 egg
-
 Nilaparvata lugens
-
1.5.1.8 additional information Nilaparvata lugens are maintained on rice variety Taichung Native 1 (TN1) for more than 170 generations under controlled conditions. Temporal transcript profile of Nllkr/sdh in nymphs and adults, quantitative real-time PCR expression analysis. Nllkr/sdh is widely expressed in the eggs, first- through fifth-instar nymphs, and adults. The expression levels varies little among different development stages Nilaparvata lugens
-
1.5.1.8 nymph
-
 Nilaparvata lugens
-
1.5.1.9 adult
-
 Nilaparvata lugens
-
1.5.1.9 egg
-
 Nilaparvata lugens
-
1.5.1.9 additional information Nilaparvata lugens are maintained on rice variety Taichung Native 1 (TN1) for more than 170 generations under controlled conditions. Temporal transcript profile of Nllkr/sdh in nymphs and adults, quantitative real-time PCR expression analysis. Nllkr/sdh is widely expressed in the eggs, first- through fifth-instar nymphs, and adults. The expression levels varies little among different development stages Nilaparvata lugens
-
1.5.1.9 nymph
-
 Nilaparvata lugens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.8 L-lysine + 2-oxoglutarate + NADPH + H+
-
 Nilaparvata lugens N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
 ?
1.5.1.8 additional information the enzyme is bifunctional catalyzing the reaction of EC 1.5.1.8, saccharopine dehydrogenase (NADP+, L-lysine-forming) in the reverse direction, and EC 1.5.1.9, saccharopine dehydrogenase (NAD+, L-glutamate-forming) Nilaparvata lugens ?
-
 ?
1.5.1.8 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
-
 Nilaparvata lugens L-lysine + 2-oxoglutarate + NADH + H+
-
 r
1.5.1.9 additional information the enzyme is bifunctional catalyzing the reaction of EC 1.5.1.8, saccharopine dehydrogenase (NADP+, L-lysine-forming) in the reverse direction, and EC 1.5.1.9, saccharopine dehydrogenase (NAD+, L-glutamate-forming) Nilaparvata lugens ?
-
 ?
1.5.1.9 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
-
 Nilaparvata lugens L-glutamate + (S)-2-amino-6-oxohexanoate + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.5.1.8 LKR/SDH
-
 Nilaparvata lugens
1.5.1.8 lysine ketoglutarate/reductase saccharopine dehydrogenase
-
 Nilaparvata lugens
1.5.1.8 nllkr/sdh
-
 Nilaparvata lugens
1.5.1.9 LKR/SDH
-
 Nilaparvata lugens
1.5.1.9 lysine ketoglutarate/reductase saccharopine dehydrogenase
-
 Nilaparvata lugens
1.5.1.9 nllkr/sdh
-
 Nilaparvata lugens

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.8 NADPH
-
 Nilaparvata lugens
1.5.1.9 NAD+
-
 Nilaparvata lugens

General Information

EC Number General Information Comment Organism
1.5.1.8 metabolism the enzyme is involved in L-lysine breakdown. In Nilaparvata lugens, the degradation of L-lysine is independent from the yeast-like endosymbionts of the organism, in contrast to degradation of other amino acids, overview Nilaparvata lugens
1.5.1.9 metabolism the enzyme is involved in L-lysine breakdown. In Nilaparvata lugens, the degradation of L-lysine is independent from the yeast-like endosymbionts of the organism, in contrast to degradation of other amino acids, overview Nilaparvata lugens