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Literature summary extracted from

  • Chen, W.; Taylor, N.L.; Chi, Y.; Millar, A.H.; Lambers, H.; Finnegan, P.M.
    The metabolic acclimation of Arabidopsis thaliana to arsenate is sensitized by the loss of mitochondrial lipoamide dehydrogenase2, a key enzyme in oxidative metabolism (2014), Plant Cell Environ., 37, 684-695 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.8.1.4 gene lpd2, recombinant expression of GUS-linked enzyme in Arabidopsis thaliana ecotype Col-0 in cotyledons, rosette leaves and roots (in the cap of the established lateral roots, but not in the cap of the main roots) via transformation by Agrobacterium tumefaciens strain GV3101 Arabidopsis thaliana

Protein Variants

EC Number Protein Variants Comment Organism
1.8.1.4 additional information generation of DLDH2 enzyme knockout mutant plants, the aos phenotype in mtlpd2-2 is due to disruption of mtLPD2. Mutation of mtLPD2 enhances As(V)-induced changes in metabolite pools, aos phenotype analysis, overview Arabidopsis thaliana

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.4 arsenite activity of lipoamide dehydrogenase in isolated mitochondria is sensitive to arsenite, but not arsenate Arabidopsis thaliana

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.8.1.4 mitochondrion
-
Arabidopsis thaliana 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.1.4 dihydrolipoamide + NAD+ Arabidopsis thaliana
-
lipoamide + NADH + H+
-
r

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.4 Arabidopsis thaliana Q9M5K2
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.4 flower
-
Arabidopsis thaliana
-
1.8.1.4 leaf
-
Arabidopsis thaliana
-
1.8.1.4 additional information mtLPD2 has a tissue-dependent expression pattern Arabidopsis thaliana
-
1.8.1.4 root
-
Arabidopsis thaliana
-
1.8.1.4 seedling
-
Arabidopsis thaliana
-
1.8.1.4 silique
-
Arabidopsis thaliana
-
1.8.1.4 stem
-
Arabidopsis thaliana
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.4 dihydrolipoamide + NAD+
-
Arabidopsis thaliana lipoamide + NADH + H+
-
r

Subunits

EC Number Subunits Comment Organism
1.8.1.4 ? x * 54000, about, sequence calculation, x * 55000, SDS-PAGE Arabidopsis thaliana

Synonyms

EC Number Synonyms Comment Organism
1.8.1.4 DLDH2
-
Arabidopsis thaliana
1.8.1.4 lipoamide dehydrogenase
-
Arabidopsis thaliana
1.8.1.4 lipoamide dehydrogenase2
-
Arabidopsis thaliana
1.8.1.4 LPD2
-
Arabidopsis thaliana
1.8.1.4 mtLPD2
-
Arabidopsis thaliana

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.4 NAD+
-
Arabidopsis thaliana
1.8.1.4 NADH
-
Arabidopsis thaliana

General Information

EC Number General Information Comment Organism
1.8.1.4 malfunction metabolic acclimation of Arabidopsis thaliana to arsenate is sensitized by the loss of mitochondrial lipoamide dehydrogenase2. Both arsenate and arsenite inhibit root elongation, decreased seedling size and increase anthocyanin production more profoundly in knockout mutants than in wild-type seedlings, arsenite seems to be the mediator of the observed phenotypes Arabidopsis thaliana
1.8.1.4 metabolism the enzyme is a key enzyme in oxidative metabolism Arabidopsis thaliana
1.8.1.4 additional information mitochondrial lipoamide dehydrogenase is an important protein for determining the sensitivity of oxidative metabolism to arsenate in Arabidopsis thaliana Arabidopsis thaliana