Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Liu, G.; Hou, G.; Li, L.; Li, Y.; Zhou, W.; Liu, L.
    Potential diagnostic and prognostic marker dimethylglycine dehydrogenase (DMGDH) suppresses hepatocellular carcinoma metastasis in vitro and in vivo (2016), Oncotarget, 7, 32607-32616 .
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
1.5.8.4 diagnostics the enzyme may be a valuable biomarker of hepatocellular carcinoma diagnosis Homo sapiens
1.5.8.4 medicine expression of DMGDH is decreased in hepatocellular carcinoma. the enzyme can be applied as valuable biomarker for both diagnosis and prognosis Homo sapiens
1.5.8.4 medicine the enzyme is biomarker for both diagnosis and prognosis for hepatocellular carcinoma Homo sapiens
1.5.8.4 medicine the enzyme may be a valuable biomarker of hepatocellular carcinoma diagnosis Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.5.8.4 mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.8.4 N,N-dimethylglycine + electron-transfer flavoprotein + H2O Homo sapiens
-
 sarcosine + formaldehyde + reduced electron-transfer flavoprotein
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.5.8.4 Homo sapiens
-
-
-
1.5.8.4 Homo sapiens Q9UI17
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.8.4 carcinoma cell hepatocellular carcinoma Homo sapiens
-
1.5.8.4 hepatocellular carcinoma cell
-
 Homo sapiens
-
1.5.8.4 hepatoma cell
-
 Homo sapiens
-
1.5.8.4 LM3 cell
-
 Homo sapiens
-
1.5.8.4 SMMC-7721 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.8.4 N,N-dimethylglycine + electron-transfer flavoprotein + H2O
-
 Homo sapiens sarcosine + formaldehyde + reduced electron-transfer flavoprotein
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.5.8.4 DMGDH
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
1.5.8.4 Homo sapiens enzyme expression is decreased in hepatocellular carcinoma down
1.5.8.4 Homo sapiens expression is decreased in hepatocellular carcinoma down

General Information

EC Number General Information Comment Organism
1.5.8.4 metabolism the phosphorylation of Akt-308/473 is significantly suppressed when the enzyme is overexpressed Homo sapiens
1.5.8.4 physiological function dimethylglycine dehydrogenase expression suppresses metastasis through the Akt signaling pathway Homo sapiens
1.5.8.4 physiological function DMGDH suppresses migration, invasion and metastasis both in vitro and in vivo. In a DMGDH over-expressing cell line, the phosphorylation of Akt-308/473 is significantly suppressed Homo sapiens
1.5.8.4 physiological function the enzyme suppresses metastasis in hepatocellular carcinoma Homo sapiens