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Literature summary extracted from

  • Ito, K.; Zolfaghari, R.; Hao, L.; Ross, A.C.
    Inflammation rapidly modulates the expression of ALDH1A1 (RALDH1) and vimentin in the liver and hepatic macrophages of rats in vivo (2014), Nutr. Metab., 11, 54 .
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
1.2.1.36 diagnostics ALDH1A1 is rapidly gaining importance as a stem cell marker Rattus norvegicus
1.2.1.36 molecular biology ALDH1A1 is rapidly gaining importance as a stem cell marker Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.2.1.36 gene Aldh1a1, quantitative reverse transcription PCR enzyme expression analysis Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.36 additional information ALDH1A1 may have a broad cellular distribution in the liver, in situ hybridization Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.36 all-trans-retinal + NAD+ + H2O Rattus norvegicus
-
 all-trans-retinoate + NADH + 2 H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.36 Rattus norvegicus P51647
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.36 hepatocyte ALDH1A1 protein exhibits diffuse staining in hepatocytes, with greater intensity in the periportal region including surrounding bile ducts Rattus norvegicus
-
1.2.1.36 liver ALDH1A1 is most highly expressed ALDH1 gene in liver Rattus norvegicus
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1.2.1.36 macrophage hepatic Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.36 all-trans-retinal + NAD+ + H2O
-
 Rattus norvegicus all-trans-retinoate + NADH + 2 H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.36 ALDH1A1
-
 Rattus norvegicus
1.2.1.36 RALDH
-
 Rattus norvegicus
1.2.1.36 RALDH1A1
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.36 NAD+
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
1.2.1.36 Rattus norvegicus inflammation reduces ALDH1A1 mRNA in whole liver regardless of the level of vitamin A in the diet, while treatment with retinal reduces ALDH1A1 expression only in chow-fed rats. Acute inflammation rapidly downregulates ALDH1A1 expression in whole liver down
1.2.1.36 Rattus norvegicus acute inflammation rapidly increases the enzyme expression in periportal macrophages up

General Information

EC Number General Information Comment Organism
1.2.1.36 evolution the enzyme is a member of the ALDH1 protein family Rattus norvegicus
1.2.1.36 malfunction acute inflammation rapidly downregulates ALDH1A1 expression in whole liver while increasing its expression in periportal macrophages Rattus norvegicus
1.2.1.36 physiological function changes in ALDH1A1 expression appear to be part of the early acute-phase inflammatory response, which alters the expression of other retinoid homeostatic genes Rattus norvegicus