EC Number | Crystallization (Comment) | Organism |
---|---|---|
1.8.4.10 | virtual ligand docking simulations with inhibitors. For 2-[(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-[(2-sulfanylethyl)amino]-9H-purin-9-yl]oxolan-2-yl]ethyl phosphate, the AMP scaffold binds within the substrate-binding pocket and establishes interactions with key active site residues | Mycobacterium tuberculosis |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.8.4.10 | 2-[(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-[(2-sulfanylethyl)amino]-9H-purin-9-yl]oxolan-2-yl]ethyl phosphate | best inhibitor analyzed. The S atom is capable of establishing favorable interactions with the Fe-S cluster | Mycobacterium tuberculosis | |
1.8.4.10 | additional information | analysis of inhibitors and molecular docking shows a clearly defined spacing requirement between the Fe-S targeting group and adenosine scaffold. Smaller Fe-S targeting groups are better tolerated. The S atom of the most potent inhibitor may establish a favorable interaction with an S atom in the cluster | Mycobacterium tuberculosis |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.8.4.10 | Mycobacterium tuberculosis | - |
- |
- |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.8.4.10 | [4Fe-4S]-center | - |
Mycobacterium tuberculosis |