Literature summary extracted from

Argueelles, A.J.; Cordell, G.A.; Maruenda, H.
Molecular docking and binding mode analysis of plant alkaloids as in vitro and in silico inhibitors of trypanothione reductase from Trypanosoma cruzi (2016), Nat. Prod. Commun., 11, 57-62 .

Crystallization (Commentary)

EC Number	Crystallization (Comment)	Organism
1.8.1.12	identification of putative inhibitors by molecular docking	Trypanosoma cruzi

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.8.1.12	(22R,25R)-solasodine	compound is an alkaloid scaffold lead in the search for inhibitors	Trypanosoma cruzi
1.8.1.12	(22R,25S)-solanidine	compound is an alkaloid scaffold lead in the search for inhibitors	Trypanosoma cruzi
1.8.1.12	(22S,25S)-tomatidine	compound is an alkaloid scaffold lead in the search for inhibitors	Trypanosoma cruzi
1.8.1.12	cephalotaxine	compound is an alkaloid scaffold lead in the search for inhibitors	Trypanosoma cruzi
1.8.1.12	cryptolepine	compound is an alkaloid scaffold lead in the search for inhibitors	Trypanosoma cruzi
1.8.1.12	quebrachamine	compound is an alkaloid scaffold lead in the search for inhibitors	Trypanosoma cruzi

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.8.1.12	Trypanosoma cruzi	-	-	-

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Release 2023.1 (January 2023)