Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Sasabe, J.; Miyoshi, Y.; Rakoff-Nahoum, S.; Zhang, T.; Mita, M.; Davis, B.M.; Hamase, K.; Waldor, M.K.
    Interplay between microbial D-amino acids and host D-amino acid oxidase modifies murine mucosal defence and gut microbiota (2016), Nat. Microbiol., 1, 16125 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
1.4.3.3 G181R inactive Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.3.3 D-Ala + H2O + O2 Mus musculus
-
 pyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-Pro + H2O + O2 Mus musculus
-
 2-oxopentanoic acid + NH3 + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.3 Mus musculus P18894
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.3 intestinal epithelial cell
-
 Mus musculus
-
1.4.3.3 intestine
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.3 D-Ala + H2O + O2
-
 Mus musculus pyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-Pro + H2O + O2
-
 Mus musculus 2-oxopentanoic acid + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.3 DAO
-
 Mus musculus

General Information

EC Number General Information Comment Organism
1.4.3.3 physiological function the enzyme plays a general role in protection at the mucosal surface. The enzyme is a microbiota-regulated host innate immune factor that modulates growth of both pathogens and commensals, primarily in the small intestine Mus musculus