Literature summary extracted from

Chen, F.; Di, H.; Wang, Y.; Cao, Q.; Xu, B.; Zhang, X.; Yang, N.; Liu, G.; Yang, C.G.; Xu, Y.; Jiang, H.; Lian, F.; Zhang, N.; Li, J.; Lan, L.
Small-molecule targeting of a diapophytoene desaturase inhibits S. aureus virulence (2016), Nat. Chem. Biol., 12, 174-179 .

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.3.8.2	naftifine	blocks biosynthesis of carotenoid pigment at nanomolar concentrations by competitive inhibition of diapophytoene desaturase CrtN. Naftifine attenuates the virulence of strain Newman and of a variety of clinical Staphylocuus aureus isolates, in mouse infection models	Staphylococcus aureus

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.3.8.2	Staphylococcus aureus	O07855	-	-
1.3.8.2	Staphylococcus aureus Newman	O07855	-	-

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Release 2023.1 (January 2023)