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Literature summary extracted from

  • Korshunov, S.; Imlay, K.R.; Imlay, J.A.
    The cytochrome bd oxidase of Escherichia coli prevents respiratory inhibition by endogenous and exogenous hydrogen sulfide (2016), Mol. Microbiol., 101, 62-77 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.3 cystine
-
Escherichia coli
7.1.1.3 Sulfide inhibition is fully reversible; low-micromolar levels of sulfide directly inhibit the proton-pumping cytochrome bo oxidase, but not cytochrome bd oxidase Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.1.1.3 ubiquinol + O2 + H+[side 1] Escherichia coli
-
ubiquinone + H2O + H+[side 2]
-
?

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.3 Escherichia coli
-
-
-
7.1.1.3 Escherichia coli P0ABJ1 and P0ABI8 and P0ABJ3 and P0ABJ6 P0ABJ1 i.e. subunit cyoA, P0ABI8 i.e. subunit cyoB, P0ABJ3 i.e. subunit cyoC, P0ABJ6 i.e. subunit cyoD
-
7.1.1.7 Escherichia coli P0ABJ9 and P0ABK2 and P56100 P0ABJ9 i.e. subunit cydA, P0ABK2 i.e. subunit cydB, P56100 i.e. subunit cydX
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.3 ubiquinol + O2 + H+[side 1]
-
Escherichia coli ubiquinone + H2O + H+[side 2]
-
?

Synonyms

EC Number Synonyms Comment Organism
7.1.1.3 cytochrome bd oxidase
-
Escherichia coli
7.1.1.3 cytochrome bo oxidase
-
Escherichia coli

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
7.1.1.3 0.005
-
cytochrome bo oxidase, at pH 7.0 and 25°C Escherichia coli Sulfide

General Information

EC Number General Information Comment Organism
7.1.1.3 physiological function the enzyme prevents respiratory inhibition by endogenous and exogenous hydrogen sulfide Escherichia coli
7.1.1.3 physiological function when cystine is provided and sulfide levels rise, Escherichia coli becomes strictly dependent upon cytochrome bd oxidase for continued respiration. Low-micromolar levels of sulfide inhibit the proton-pumping cytochrome bo oxidase. In the absence of the back-up cytochrome bd oxidase, growth fails. Exogenous sulfide elicits the same effect Escherichia coli
7.1.1.7 physiological function when cystine is provided and sulfide levels rise, Escherichia coli becomes strictly dependent upon cytochrome bd oxidase for continued respiration. Low-micromolar levels of sulfide inhibit the proton-pumping cytochrome bo oxidase. In the absence of the back-up cytochrome bd oxidase, growth fails. Exogenous sulfide elicits the same effect Escherichia coli