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Literature summary extracted from

  • Li, R.; Li, H.; Sun, Q.; Liu, L.; Zhang, C.; Ren, X.
    Indoleamine 2,3-dioxygenase regulates T cell activity through Vav1/Rac pathway (2017), Mol. Immunol., 81, 102-107 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.13.11.52 recombinant overexpression of enzyme IDO in HEK-293 cells Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.52 D-tryptophan + O2 Homo sapiens
-
 N-formyl-D-kynurenine
-
 ?
1.13.11.52 L-tryptophan + O2 Homo sapiens
-
 N-formyl-L-kynurenine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.52 Homo sapiens P14902
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.52 T-lymphocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.52 D-tryptophan + O2
-
 Homo sapiens N-formyl-D-kynurenine
-
 ?
1.13.11.52 L-tryptophan + O2
-
 Homo sapiens N-formyl-L-kynurenine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.52 IDO
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.13.11.52 heme
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.13.11.52 physiological function the immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO) suppresses T-cell responses and promotes immune tolerance in tumor resistance, indoleamine 2,3-dioxygenase regulates T cell activity through Vav1/Rac pathway, the inhibitory effects of IDO on T cell immune responses may occur through the downregulation of Vav1 protein expression and the suppression of Vav1/Rac cascade . Enzyme IDO cannot downregulate the expression of the two early signal transductions, namely, ZAP-70 and CD3lambda Homo sapiens