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Literature summary extracted from

  • Surve, S.V.; Jensen, B.C.; Heestand, M.; Mazet, M.; Smith, T.K.; Bringaud, F.; Parsons, M.; Schnaufer, A.
    NADH dehydrogenase of Trypanosoma brucei is important for efficient acetate production in bloodstream forms (2017), Mol. Biochem. Parasitol., 211, 57-61 .
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.2 mitochondrion
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 Trypanosoma brucei 5739
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Organism

EC Number Organism UniProt Comment Textmining
7.1.1.2 Trypanosoma brucei
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-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Synonyms

EC Number Synonyms Comment Organism
7.1.1.2 NDH2
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 Trypanosoma brucei

General Information

EC Number General Information Comment Organism
7.1.1.2 physiological function inducible knockdown of NDH2 has a modest growth effect in bloodstream forms, but NDH2 null mutants, as well as inducible knockdowns in a complex I deficient back-ground, show a greater reduction in growth. Loss of NDH2 leads to reduced levels of acetate, which is required for several essential pathways in bloodstream form Trypanosoma brucei Trypanosoma brucei