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Literature summary extracted from

  • Li, X.; Huang, R.; Xie, Z.; Lin, M.; Liang, Z.; Yang, Y.; Jiang, W.
    Renalase, a new secretory enzyme Its role in hypertensive-ischemic cardiovascular diseases (2014), Med. Sci. Monit., 20, 688-692 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.6.3.5 dopamine + O2 Homo sapiens
-
?
-
?
1.6.3.5 epinephrine + O2 Homo sapiens
-
?
-
?
1.6.3.5 L-DOPA + O2 Homo sapiens
-
?
-
?
1.6.3.5 norepinephrine + O2 Homo sapiens
-
?
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.6.3.5 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.3.5 blood
-
Homo sapiens
-
1.6.3.5 brain
-
Homo sapiens
-
1.6.3.5 heart
-
Homo sapiens
-
1.6.3.5 kidney
-
Homo sapiens
-
1.6.3.5 skeletal muscle
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.3.5 dopamine + O2
-
Homo sapiens ?
-
?
1.6.3.5 epinephrine + O2
-
Homo sapiens ?
-
?
1.6.3.5 L-DOPA + O2
-
Homo sapiens ?
-
?
1.6.3.5 norepinephrine + O2
-
Homo sapiens ?
-
?

Subunits

EC Number Subunits Comment Organism
1.6.3.5 ? x * 37800, calculated from amino acid sequence Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.6.3.5 FAD
-
Homo sapiens
1.6.3.5 NADH
-
Homo sapiens
1.6.3.5 NADPH
-
Homo sapiens

General Information

EC Number General Information Comment Organism
1.6.3.5 physiological function renalase participates in the pathophysiological mechanism of cardiac dysfunction by down-regulating the activity of sympathetic nervous system and degrading the level of catecholamines. Renalase is strongly associated with type 1 diabetes, hypertension and ischemic diseases Homo sapiens