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Literature summary extracted from

  • Yoshiya, T.; Ii, H.; Tsuda, S.; Mochizuki, M.; Kageyama, S.; Yoshiki, T.
    Design of fluorogenic probes and fluorescent-tagged inhibitors for gamma-glutamyl cyclotransferase (2017), J. Pept. Sci., 23, 618-623 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.3.2.9 glutaryl-L-Ala 54% inhibition Homo sapiens
4.3.2.9 N2-(4-carboxybutanoyl)-N6-(7-nitro-2,1,3-benzoxadiazol-4-yl)-L-lysine 53% inhibition Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.3.2.9 0.28
-
gamma-L-Glu-epsilon-N-benzyloxycarbonyl-L-Lys pH 6.5, temperature not specified in the publication Homo sapiens
4.3.2.9 0.32
-
gamma-L-Glu-epsilon-N-benzyloxycarbonyl-L-Lys pH 8.0, temperature not specified in the publication Homo sapiens
4.3.2.9 0.38
-
L-gamma-glutamyl-O-[(4-methylumbelliferyl)carbonyl]-L-serine pH 6.5, temperature not specified in the publication Homo sapiens
4.3.2.9 0.56
-
N5-((S)-1-carboxy-3-(ethyl(((3-oxo-3H-phenoxazin-7-yl)oxy)carbonyl)amino)propyl)-L-glutamine pH 8.0, temperature not specified in the publication Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
4.3.2.9 Homo sapiens O75223
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.3.2.9 NIH-3T3 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.2.9 gamma-L-Glu-epsilon-N-benzyloxycarbonyl-L-Lys
-
Homo sapiens epsilon-N-benzyloxycarbonyl-L-Lys + 5-oxo-L-proline
-
?
4.3.2.9 L-gamma-glutamyl-O-[(4-methylumbelliferyl)carbonyl]-L-serine fluorogenic probe Homo sapiens (2S)-2-amino-3-([[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]carbonyl]oxy)propanoic acid + 5-oxo-L-proline
-
?
4.3.2.9 N5-((S)-1-carboxy-3-(ethyl(((3-oxo-3H-phenoxazin-7-yl)oxy)carbonyl)amino)propyl)-L-glutamine fluorogenic probe Homo sapiens (2S)-2-amino-4-(ethyl[[(3-oxo-3H-phenoxazin-7-yl)oxy]carbonyl]amino)butanoic acid + 5-oxo-L-proline
-
?

Synonyms

EC Number Synonyms Comment Organism
4.3.2.9 C7orf24
-
Homo sapiens
4.3.2.9 GGCT
-
Homo sapiens