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Literature summary extracted from

  • Sampaio, T.B.; Da Rocha, J.T.; Prigol, M.; Saraiva, R.A.; Nogara, P.F.; Stein, A.L.; da Rocha, J.B.; Zeni, G.; Nogueira, C.W.
    4-Organoseleno-isoquinolines selectively and reversibly inhibit the cerebral monoamine oxidase B activity (2016), J. Mol. Neurosci., 59, 135-145 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.4 3-phenyl-4-(phenylseleno)isoquinoline reversibly inhibits isoform MAO-B activity Rattus norvegicus
1.4.3.4 3-phenyl-4-(phenylthio)isoquinoline
-
 Rattus norvegicus
1.4.3.4 4-(4-fluorophenylseleno)-3-phenylisoquinoline
-
 Rattus norvegicus
1.4.3.4 additional information 3-phenyl-4-(phenyltelluro) isoquinoline does not inhibit 50% of the isoform MAO-B activity up to concentration of 0.1 mM Rattus norvegicus
1.4.3.4 rasagiline specific MAO-B inhibitor Rattus norvegicus
1.4.3.4 selegiline specific MAO-B inhibitor Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.4.3.4 mitochondrion
-
 Rattus norvegicus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.4 Rattus norvegicus P19643
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.4 brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.4 kynuramine + O2
-
 Rattus norvegicus 4-hydroxyquinoline + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.4 MAO-B isoform Rattus norvegicus
1.4.3.4 monoamine oxidase B
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.3.4 FAD
-
 Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.4.3.4 0.03645
-
 isoform MAO-B, at pH 7.4 and 37°C Rattus norvegicus 3-phenyl-4-(phenylseleno)isoquinoline
1.4.3.4 0.07586
-
 isoform MAO-B, at pH 7.4 and 37°C Rattus norvegicus 3-phenyl-4-(phenylthio)isoquinoline
1.4.3.4 0.08241
-
 isoform MAO-B, at pH 7.4 and 37°C Rattus norvegicus 4-(4-fluorophenylseleno)-3-phenylisoquinoline