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Literature summary extracted from

  • Jung, H.J.; Cho, M.; Kim, Y.; Han, G.; Kwon, H.J.
    Development of a novel class of mitochondrial ubiquinol-cytochrome c reductase binding protein (UQCRB) modulators as promising antiangiogenic leads (2014), J. Med. Chem., 57, 7990-7998 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.8 4-ethyl-N-(4-hydroxyphenyl)benzenesulfonamide
-
 Homo sapiens
7.1.1.8 4-tert-butyl-N-(2-hydroxyphenyl)benzenesulfonamide
-
 Homo sapiens
7.1.1.8 4-tert-butyl-N-(3-hydroxyphenyl)benzenesulfonamide
-
 Homo sapiens
7.1.1.8 4-tert-butyl-N-(4-hydroxynaphthalen-1-yl)benzenesulfonamide
-
 Homo sapiens
7.1.1.8 4-tert-butyl-N-(4-hydroxyphenyl)benzenesulfonamide
-
 Homo sapiens
7.1.1.8 4-tert-butyl-N-(8-hydroxyquinolin-5-yl)benzenesulfonamide
-
 Homo sapiens
7.1.1.8 5-(biphenyl-4-ylsulfonamido)-2-hydroxybenzoic acid
-
 Homo sapiens
7.1.1.8 6-((1-hydroxynaphthalen-4-ylamino)dioxysulfone)-2H-naphtho[1,8-bc]thiophen-2-one
-
 Homo sapiens
7.1.1.8 N-(3-chloro-4-hydroxyphenyl)biphenyl-4-sulfonamide
-
 Homo sapiens
7.1.1.8 N-(3-fluoro-4-hydroxyphenyl)biphenyl-4-sulfonamide
-
 Homo sapiens
7.1.1.8 N-(4-hydroxynaphthalen-1-yl)biphenyl-4-sulfonamide
-
 Homo sapiens
7.1.1.8 N-(4-hydroxyphenyl)-4-methylbenzenesulfonamide
-
 Homo sapiens
7.1.1.8 N-(4-hydroxyphenyl)biphenyl-4-sulfonamide
-
 Homo sapiens
7.1.1.8 N-(4-hydroxyphenyl)naphthalene-2-sulfonamide
-
 Homo sapiens
7.1.1.8 N-(4-hydroxyphenyl)quinoline-8-sulfonamide
-
 Homo sapiens
7.1.1.8 N-(5-hydroxynaphthalen-1-yl)biphenyl-4-sulfonamide
-
 Homo sapiens
7.1.1.8 N-(7-hydroxynaphthalen-1-yl)biphenyl-4-sulfonamide
-
 Homo sapiens
7.1.1.8 N-(8-hydroxyquinolin-5-yl)biphenyl-4-sulfonamide
-
 Homo sapiens
7.1.1.8 potassium 4-(biphenyl-4-ylsulfonamido)phenolate
-
 Homo sapiens
7.1.1.8 terpestacin
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.8 mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.1.1.8 quinol + 2 ferricytochrome c Homo sapiens
-
 quinone + 2 ferrocytochrome c + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.8 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.1.1.8 HUVEC cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.8 quinol + 2 ferricytochrome c
-
 Homo sapiens quinone + 2 ferrocytochrome c + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.1.1.8 ubiquinol-cytochrome c reductase binding protein
-
 Homo sapiens
7.1.1.8 UQCRB
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
7.1.1.8 cytochrome c
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
7.1.1.8 0.0025
-
 pH and temperature not specified in the publication Homo sapiens N-(4-hydroxyphenyl)biphenyl-4-sulfonamide
7.1.1.8 0.005
-
 pH and temperature not specified in the publication Homo sapiens 4-tert-butyl-N-(4-hydroxyphenyl)benzenesulfonamide
7.1.1.8 0.005
-
 pH and temperature not specified in the publication Homo sapiens potassium 4-(biphenyl-4-ylsulfonamido)phenolate
7.1.1.8 0.005
-
 pH and temperature not specified in the publication Homo sapiens 6-((1-hydroxynaphthalen-4-ylamino)dioxysulfone)-2H-naphtho[1,8-bc]thiophen-2-one
7.1.1.8 0.008
-
 pH and temperature not specified in the publication Homo sapiens 4-tert-butyl-N-(2-hydroxyphenyl)benzenesulfonamide
7.1.1.8 0.02
-
 pH and temperature not specified in the publication Homo sapiens 4-tert-butyl-N-(4-hydroxynaphthalen-1-yl)benzenesulfonamide
7.1.1.8 0.02
-
 pH and temperature not specified in the publication Homo sapiens 4-tert-butyl-N-(8-hydroxyquinolin-5-yl)benzenesulfonamide
7.1.1.8 0.02
-
 pH and temperature not specified in the publication Homo sapiens N-(8-hydroxyquinolin-5-yl)biphenyl-4-sulfonamide
7.1.1.8 0.02
-
 IC50 above 0.02 mM, pH and temperature not specified in the publication Homo sapiens N-(4-hydroxyphenyl)-4-methylbenzenesulfonamide
7.1.1.8 0.02
-
 IC50 above 0.02 mM, pH and temperature not specified in the publication Homo sapiens 4-ethyl-N-(4-hydroxyphenyl)benzenesulfonamide
7.1.1.8 0.02
-
 IC50 above 0.02 mM, pH and temperature not specified in the publication Homo sapiens N-(3-fluoro-4-hydroxyphenyl)biphenyl-4-sulfonamide
7.1.1.8 0.02
-
 IC50 above 0.02 mM, pH and temperature not specified in the publication Homo sapiens N-(3-chloro-4-hydroxyphenyl)biphenyl-4-sulfonamide
7.1.1.8 0.02
-
 IC50 above 0.02 mM, pH and temperature not specified in the publication Homo sapiens 5-(biphenyl-4-ylsulfonamido)-2-hydroxybenzoic acid
7.1.1.8 0.02
-
 IC50 above 0.02 mM, pH and temperature not specified in the publication Homo sapiens N-(4-hydroxynaphthalen-1-yl)biphenyl-4-sulfonamide
7.1.1.8 0.02
-
 IC50 above 0.02 mM, pH and temperature not specified in the publication Homo sapiens N-(5-hydroxynaphthalen-1-yl)biphenyl-4-sulfonamide
7.1.1.8 0.02
-
 IC50 above 0.02 mM, pH and temperature not specified in the publication Homo sapiens N-(7-hydroxynaphthalen-1-yl)biphenyl-4-sulfonamide
7.1.1.8 0.02
-
 IC50 above 0.02 mM, pH and temperature not specified in the publication Homo sapiens N-(4-hydroxyphenyl)naphthalene-2-sulfonamide
7.1.1.8 0.02
-
 IC50 above 0.02 mM, pH and temperature not specified in the publication Homo sapiens N-(4-hydroxyphenyl)quinoline-8-sulfonamide
7.1.1.8 0.098
-
 pH and temperature not specified in the publication Homo sapiens 4-tert-butyl-N-(3-hydroxyphenyl)benzenesulfonamide