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Literature summary extracted from

  • Natarajan, S.K.; Muthukrishnan, E.; Khalimonchuk, O.; Mott, J.L.; Becker, D.F.
    Evidence for pipecolate oxidase in mediating protection against hydrogen peroxide stress (2017), J. Cell. Biochem., 118, 1678-1688 .
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.5.3.7 mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.3.7 L-pipecolate + O2 Homo sapiens pipecolate metabolism leads to protection against H2O2 stress in mammalian cells. The enzyme is necessary for pipecolate protection (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2
-
 ?
1.5.3.7 L-pipecolate + O2 Homo sapiens
-
 DELTA1-piperideine-6-carboxylate + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.5.3.7 Homo sapiens
-
-
-
1.5.3.7 Homo sapiens Q9P0Z9
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.3.7 HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.3.7 L-pipecolate + O2
-
 Homo sapiens (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2
-
 ?
1.5.3.7 L-pipecolate + O2 pipecolate metabolism leads to protection against H2O2 stress in mammalian cells. The enzyme is necessary for pipecolate protection Homo sapiens (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2
-
 ?
1.5.3.7 L-pipecolate + O2
-
 Homo sapiens DELTA1-piperideine-6-carboxylate + H2O2
-
 ?
1.5.3.7 L-proline + O2
-
 Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.5.3.7 ? x * 44000, calculated from amino acid sequence Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.5.3.7 L-pipecolate oxidase
-
 Homo sapiens
1.5.3.7 PIPOX
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.3.7 FAD
-
 Homo sapiens
1.5.3.7 FAD flavoenzyme Homo sapiens

General Information

EC Number General Information Comment Organism
1.5.3.7 malfunction knockdown of the enzyme by small interference RNA abolishes pipecolate protection against hydrogen peroxide-induced cell death in HEK293 cells suggesting a critical role for this enzyme Homo sapiens
1.5.3.7 physiological function pipecolate metabolism leads to protection against H2O2 stress in mammalian cells. The enzyme is necessary for pipecolate protection Homo sapiens