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Literature summary extracted from

  • Kudo, F.; Matsuura, Y.; Hayashi, T.; Fukushima, M.; Eguchi, T.
    Genome mining of the sordarin biosynthetic gene cluster from Sordaria araneosa Cain ATCC 36386 characterization of cycloaraneosene synthase and GDP-6-deoxyaltrose transferase (2016), J. Antibiot., 69, 541-548 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.353 expression in Escherichia coli Sordaria araneosa
4.2.3.191 expression in Escherichia coli Sordaria araneosa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.2.3.191 Mg2+ required Sordaria araneosa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.353 ADP-6-deoxy-alpha-D-altrose + sordaricin Sordaria araneosa poor substrate: ADP-6-deoxy-alpha-D-altrose 4'-O-demethylsordarin + ADP
-
 ?
2.4.1.353 ADP-6-deoxy-alpha-D-altrose + sordaricin Sordaria araneosa ATCC 36386 poor substrate: ADP-6-deoxy-alpha-D-altrose 4'-O-demethylsordarin + ADP
-
 ?
2.4.1.353 GDP-6-deoxy-alpha-D-altrose + sordaricin Sordaria araneosa
-
 4'-O-demethylsordarin + GDP
-
 ?
2.4.1.353 GDP-6-deoxy-alpha-D-altrose + sordaricin Sordaria araneosa ATCC 36386
-
 4'-O-demethylsordarin + GDP
-
 ?
2.4.1.353 GDP-alpha-D-mannose + sordaricin Sordaria araneosa
-
 2'-O-beta-D-mannosylsordaricin + GDP
-
 ?
2.4.1.353 GDP-alpha-D-mannose + sordaricin Sordaria araneosa ATCC 36386
-
 2'-O-beta-D-mannosylsordaricin + GDP
-
 ?
2.4.1.353 additional information Sordaria araneosa glycosyltransferase SdnJ catalyzes the glycosylation of sordaricin in the presence of GDP-6-deoxy-D-altrose to give 4'-O-demethylsordarin ?
-
 ?
2.4.1.353 additional information Sordaria araneosa no substrate: TDP-6-deoxy-alpha-D-altrose, GDP-D-glucose ?
-
 ?
2.4.1.353 additional information Sordaria araneosa ATCC 36386 glycosyltransferase SdnJ catalyzes the glycosylation of sordaricin in the presence of GDP-6-deoxy-D-altrose to give 4'-O-demethylsordarin ?
-
 ?
2.4.1.353 additional information Sordaria araneosa ATCC 36386 no substrate: TDP-6-deoxy-alpha-D-altrose, GDP-D-glucose ?
-
 ?
4.2.3.191 geranylgeranyl diphosphate Sordaria araneosa
-
 cycloaraneosene + diphosphate
-
 ?
4.2.3.191 geranylgeranyl diphosphate Sordaria araneosa ATCC 36386
-
 cycloaraneosene + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.353 Sordaria araneosa A0A1B4XBH6
-
-
2.4.1.353 Sordaria araneosa ATCC 36386 A0A1B4XBH6
-
-
4.2.3.191 Sordaria araneosa A0A1B4XBG5
-
-
4.2.3.191 Sordaria araneosa ATCC 36386 A0A1B4XBG5
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.353 ADP-6-deoxy-alpha-D-altrose + sordaricin poor substrate: ADP-6-deoxy-alpha-D-altrose Sordaria araneosa 4'-O-demethylsordarin + ADP
-
 ?
2.4.1.353 ADP-6-deoxy-alpha-D-altrose + sordaricin poor substrate: ADP-6-deoxy-alpha-D-altrose Sordaria araneosa ATCC 36386 4'-O-demethylsordarin + ADP
-
 ?
2.4.1.353 GDP-6-deoxy-alpha-D-altrose + sordaricin
-
 Sordaria araneosa 4'-O-demethylsordarin + GDP
-
 ?
2.4.1.353 GDP-6-deoxy-alpha-D-altrose + sordaricin
-
 Sordaria araneosa ATCC 36386 4'-O-demethylsordarin + GDP
-
 ?
2.4.1.353 GDP-alpha-D-mannose + sordaricin
-
 Sordaria araneosa 2'-O-beta-D-mannosylsordaricin + GDP
-
 ?
2.4.1.353 GDP-alpha-D-mannose + sordaricin
-
 Sordaria araneosa ATCC 36386 2'-O-beta-D-mannosylsordaricin + GDP
-
 ?
2.4.1.353 additional information glycosyltransferase SdnJ catalyzes the glycosylation of sordaricin in the presence of GDP-6-deoxy-D-altrose to give 4'-O-demethylsordarin Sordaria araneosa ?
-
 ?
2.4.1.353 additional information no substrate: TDP-6-deoxy-alpha-D-altrose, GDP-D-glucose Sordaria araneosa ?
-
 ?
2.4.1.353 additional information glycosyltransferase SdnJ catalyzes the glycosylation of sordaricin in the presence of GDP-6-deoxy-D-altrose to give 4'-O-demethylsordarin Sordaria araneosa ATCC 36386 ?
-
 ?
2.4.1.353 additional information no substrate: TDP-6-deoxy-alpha-D-altrose, GDP-D-glucose Sordaria araneosa ATCC 36386 ?
-
 ?
4.2.3.191 geranylgeranyl diphosphate
-
 Sordaria araneosa cycloaraneosene + diphosphate
-
 ?
4.2.3.191 geranylgeranyl diphosphate
-
 Sordaria araneosa ATCC 36386 cycloaraneosene + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.353 GDP-6-deoxyaltrose transferase
-
 Sordaria araneosa
2.4.1.353 SdnJ
-
 Sordaria araneosa
4.2.3.191 SdnA
-
 Sordaria araneosa

General Information

EC Number General Information Comment Organism
4.2.3.191 physiological function forms part of the sdn gene cluster responsible for the sordarin/hypoxysordarin biosynthesis Sordaria araneosa