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Literature summary extracted from

  • Eleftheriadis, T.; Pissas, G.; Antoniadi, G.; Liakopoulos, V.; Stefanidis, I.
    Indoleamine 2,3-dioxygenase depletes tryptophan, activates general control non-derepressible 2 kinase and down-regulates key enzymes involved in fatty acid synthesis in primary human CD4+ T cells (2015), Immunology, 146, 292-300 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.52 1-methyl-DL-tryptophan
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.52 D-tryptophan + O2 Homo sapiens
-
 N-formyl-D-kynurenine
-
 ?
1.13.11.52 L-tryptophan + O2 Homo sapiens
-
 N-formyl-L-kynurenine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.52 Homo sapiens P14902
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.52 lymphocyte
-
 Homo sapiens
-
1.13.11.52 additional information indoleamine 2,3-dioxygenase is expressed in antigen-presenting cells and exerts immunosuppressive effects on CD4+ T cells through the inhibition of aerobic glycolysis or through downregulation of key enzymes that directly or indirectly promote fatty acid synthesis, a prerequisite for CD4+ T-cell proliferation and differentiation into effector cell lineages Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.52 D-tryptophan + O2
-
 Homo sapiens N-formyl-D-kynurenine
-
 ?
1.13.11.52 L-tryptophan + O2
-
 Homo sapiens N-formyl-L-kynurenine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.52 IDO
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.13.11.52 heme
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.13.11.52 physiological function indoleamine 2,3-dioxygenase depletes tryptophan, activates general control non-derepressible 2 kinase and down-regulates key enzymes involved in fatty acid synthesis in primary human CD4+ T cells. Indoleamine 2,3-dioxygenase is expressed in antigen-presenting cells and exerts immunosuppressive effects on CD4+ T cells through the inhibition of aerobic glycolysis or through downregulation of key enzymes that directly or indirectly promote fatty acid synthesis, a prerequisite for CD4+ T-cell proliferation and differentiation into effector cell lineages. IDO activates GCN2 kinase which inhibits CD4+ T-cell proliferation Homo sapiens