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Literature summary extracted from

  • Garcia, P.; Moreau, A.; Ierich, J.; Vig, A.; Higa, A.; Oliveira, G.; Abdalla, F.; Hausen, M.; Leite, F.
    A nanobiosensor based on 4-hydroxyphenylpyruvate dioxygenase enzyme for mesotrione detection (2015), IEEE Sens. J., 15, 2106-2113 .
No PubMed abstract available

Application

EC Number Application Comment Organism
1.13.11.27 diagnostics the enzyme can be used for enzyme-based sensors for monitoring herbicides used in agriculture, i.e. mesotrione. Compared to the standard sensors, biosensors have assorted advantages, such as practicality, quick response, low cost, and high sensitivity. A nanobiosensor is developed based on HPPD for mesotrione detection Homo sapiens
1.13.11.27 environmental protection the enzyme can be used for enzyme-based sensors for monitoring herbicides used in agriculture, i.e. mesotrione. Compared to the standard sensors, biosensors have assorted advantages, such as practicality, quick response, low cost, and high sensitivity. A nanobiosensor is developed based on HPPD for mesotrione detection Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.13.11.27 additional information construction of a nanobiosensor based on HPPD for mesotrione detection. The atomic force microscope tip functionalization with HPPD immobilized in self-assembled monolayers is confirmed by fluorescence microscopy and atomic force spectroscopy. The cross-linker N-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride is responsible for properly preserving the enzyme on the tip Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.27 mesotrione molecular docking and molecular dynamics simulation estimate the interacting regions of HPPD with mesotrione using structure PDB ID 3ISQ Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.27 4-hydroxyphenylpyruvate + O2 Homo sapiens
-
 homogentisate + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.27 Homo sapiens P32754
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.27 commercial preparation pure enzyme Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.27 4-hydroxyphenylpyruvate + O2
-
 Homo sapiens homogentisate + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.27 HPPD
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.13.11.27 0.000068 0.0236 mesotrione dependent on the system used, overview. pH and temperature not specified in the publication Homo sapiens