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Literature summary extracted from

  • Ceci, R.; Duranti, G.; Leonetti, A.; Pietropaoli, S.; Spinozzi, F.; Marcocci, L.; Amendola, R.; Cecconi, F.; Sabatini, S.; Mariottini, P.; Cervelli, M.
    Adaptive responses of heart and skeletal muscle to spermine oxidase overexpression Evaluation of a new transgenic mouse model (2017), Free Radic. Biol. Med., 103, 216-225 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.3.16 spermine + O2 + H2O Mus musculus the enzyme is involved in cell drug response, apoptosis, and in the etiology of several pathologies, including cancer. The Total-Smox line is a genetic model useful to deepen the knowledge on the role of spermine oxidase in muscle atrophy and muscular pathological conditions like dystrophy spermidine + 3-aminopropanal + H2O2
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Organism

EC Number Organism UniProt Comment Textmining
1.5.3.16 Mus musculus Q99K82
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.3.16 brain
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Mus musculus
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1.5.3.16 heart
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Mus musculus
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1.5.3.16 intestine
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Mus musculus
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1.5.3.16 liver
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Mus musculus
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1.5.3.16 lung
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Mus musculus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.3.16 spermine + O2 + H2O
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Mus musculus spermidine + 3-aminopropanal + H2O2
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?
1.5.3.16 spermine + O2 + H2O the enzyme is involved in cell drug response, apoptosis, and in the etiology of several pathologies, including cancer. The Total-Smox line is a genetic model useful to deepen the knowledge on the role of spermine oxidase in muscle atrophy and muscular pathological conditions like dystrophy Mus musculus spermidine + 3-aminopropanal + H2O2
-
?

General Information

EC Number General Information Comment Organism
1.5.3.16 physiological function the enzyme is involved in cell drug response, apoptosis, and in the etiology of several pathologies, including cancer. The Total-Smox line is a genetic model useful to deepen the knowledge on the role of spermine oxidase in muscle atrophy and muscularpathological conditions like dystrophy Mus musculus