EC Number | Cloned (Comment) | Organism |
---|---|---|
6.2.1.50 | expression in Escherichia coli | Mycobacterium tuberculosis |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
6.2.1.50 | 4-hydroxybenzoyl-adenylate + holo-[4-hydroxyphenylalkanoate synthase] | Mycobacterium tuberculosis | - |
AMP + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase] | - |
? | |
6.2.1.50 | 4-hydroxybenzoyl-adenylate + holo-[4-hydroxyphenylalkanoate synthase] | Mycobacterium tuberculosis H37Rv | - |
AMP + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase] | - |
? | |
6.2.1.50 | ATP + 4-hydroxybenzoate | Mycobacterium tuberculosis | - |
4-hydroxybenzoyl-adenylate + diphosphate | - |
? | |
6.2.1.50 | ATP + 4-hydroxybenzoate | Mycobacterium tuberculosis H37Rv | - |
4-hydroxybenzoyl-adenylate + diphosphate | - |
? | |
6.2.1.50 | ATP + 4-hydroxybenzoate + holo-[4-hydroxyphenylalkanoate synthase] | Mycobacterium tuberculosis | - |
AMP + diphosphate + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase] | - |
? | |
6.2.1.50 | ATP + 4-hydroxybenzoate + holo-[4-hydroxyphenylalkanoate synthase] | Mycobacterium tuberculosis H37Rv | - |
AMP + diphosphate + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase] | - |
? | |
6.2.1.50 | additional information | Mycobacterium tuberculosis | FadD22 displays a 4-hydroxybenzoyl-AMP ligase activity. No substrate: laurate | ? | - |
? | |
6.2.1.50 | additional information | Mycobacterium tuberculosis H37Rv | FadD22 displays a 4-hydroxybenzoyl-AMP ligase activity. No substrate: laurate | ? | - |
? | |
6.2.1.59 | a long-chain fatty-acyl adenylate ester + holo-[(phenol)carboxyphthiodiolenone synthase] | Mycobacterium tuberculosis variant bovis | - |
AMP + a long-chain acyl-[(phenol)carboxyphthiodiolenone synthase] | - |
? | |
6.2.1.59 | ATP + a long-chain fatty acid | Mycobacterium tuberculosis variant bovis | - |
diphosphate + a long-chain fatty-acyl adenylate ester | - |
? | |
6.2.1.59 | ATP + a long-chain fatty acid + holo-[(phenol)carboxyphthiodiolenone synthase] | Mycobacterium tuberculosis variant bovis | - |
AMP + diphosphate + a long-chain acyl-[(phenol)carboxyphthiodiolenone synthase] | - |
? | |
6.2.1.59 | additional information | Mycobacterium tuberculosis variant bovis | in vivo, FadD26 specificallyactivates C22-24 fatty acyl chains that are loaded onto phenolcarboxyphthiodiolenone synthase PpsA for the formation of the phthiocerol chain, but FadD26 is not required for the production of phenolic glycolipids | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
6.2.1.50 | Mycobacterium tuberculosis | P9WQ61 | - |
- |
6.2.1.50 | Mycobacterium tuberculosis H37Rv | P9WQ61 | - |
- |
6.2.1.59 | Mycobacterium tuberculosis variant bovis | A0A0H3M8A6 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
6.2.1.50 | 4-hydroxybenzoyl-adenylate + holo-[4-hydroxyphenylalkanoate synthase] | - |
Mycobacterium tuberculosis | AMP + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase] | - |
? | |
6.2.1.50 | 4-hydroxybenzoyl-adenylate + holo-[4-hydroxyphenylalkanoate synthase] | - |
Mycobacterium tuberculosis H37Rv | AMP + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase] | - |
? | |
6.2.1.50 | ATP + 4-hydroxybenzoate | - |
Mycobacterium tuberculosis | 4-hydroxybenzoyl-adenylate + diphosphate | - |
? | |
6.2.1.50 | ATP + 4-hydroxybenzoate | - |
Mycobacterium tuberculosis H37Rv | 4-hydroxybenzoyl-adenylate + diphosphate | - |
? | |
6.2.1.50 | ATP + 4-hydroxybenzoate + holo-[4-hydroxyphenylalkanoate synthase] | - |
Mycobacterium tuberculosis | AMP + diphosphate + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase] | - |
? | |
6.2.1.50 | ATP + 4-hydroxybenzoate + holo-[4-hydroxyphenylalkanoate synthase] | - |
Mycobacterium tuberculosis H37Rv | AMP + diphosphate + 4-hydroxybenzoyl-[4-hydroxyphenylalkanoate synthase] | - |
? | |
6.2.1.50 | additional information | FadD22 displays a 4-hydroxybenzoyl-AMP ligase activity. No substrate: laurate | Mycobacterium tuberculosis | ? | - |
? | |
6.2.1.50 | additional information | FadD22 displays a 4-hydroxybenzoyl-AMP ligase activity. No substrate: laurate | Mycobacterium tuberculosis H37Rv | ? | - |
? | |
6.2.1.59 | a long-chain fatty-acyl adenylate ester + holo-[(phenol)carboxyphthiodiolenone synthase] | - |
Mycobacterium tuberculosis variant bovis | AMP + a long-chain acyl-[(phenol)carboxyphthiodiolenone synthase] | - |
? | |
6.2.1.59 | ATP + a long-chain fatty acid | - |
Mycobacterium tuberculosis variant bovis | diphosphate + a long-chain fatty-acyl adenylate ester | - |
? | |
6.2.1.59 | ATP + a long-chain fatty acid + holo-[(phenol)carboxyphthiodiolenone synthase] | - |
Mycobacterium tuberculosis variant bovis | AMP + diphosphate + a long-chain acyl-[(phenol)carboxyphthiodiolenone synthase] | - |
? | |
6.2.1.59 | additional information | in vivo, FadD26 specificallyactivates C22-24 fatty acyl chains that are loaded onto phenolcarboxyphthiodiolenone synthase PpsA for the formation of the phthiocerol chain, but FadD26 is not required for the production of phenolic glycolipids | Mycobacterium tuberculosis variant bovis | ? | - |
? | |
6.2.1.59 | additional information | in vivo, FadD26 specifically activates C22-24 fatty acyl chains that are loaded onto phenolcarboxyphthiodiolenone synthase PpsA for the formation of the phthiocerol chain, but FadD26 is not required for the production of phenolic glycolipids | Mycobacterium tuberculosis variant bovis | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
6.2.1.50 | fadD22 | - |
Mycobacterium tuberculosis |
6.2.1.50 | p-hydroxybenzoic acid-AMP ligase | - |
Mycobacterium tuberculosis |
EC Number | General Information | Comment | Organism |
---|---|---|---|
6.2.1.50 | physiological function | disruption of FadD22 abolishes the production of its species-specific phenolic glycolipid | Mycobacterium tuberculosis |
6.2.1.59 | physiological function | FadD26 is required for the production of phthiodiolone dimycocerosates but not of phenolic glycolipids. Disruption of FadD26 in Mycobacterium bovis BCG abolishes the production of phthiocerol dimycocerosate (DIM A) and of phthiodiolone dimycocerosate (DIM B) | Mycobacterium tuberculosis variant bovis |