Literature summary extracted from
Plancarte, A.; Nava, G.; Munguia, J.A.
A new thioredoxin reductase with additional glutathione reductase activity in Haemonchus contortus (2017), Exp. Parasitol., 177, 82-92 .
Inhibitors
EC Number |
Inhibitors |
Comment |
Organism |
Structure |
---|
1.8.1.7 |
NADP+ |
competitive |
Haemonchus contortus |
|
1.8.1.7 |
Zn2+ |
2 mM, complete inhibition |
Haemonchus contortus |
|
KM Value [mM]
EC Number |
KM Value [mM] |
KM Value Maximum [mM] |
Substrate |
Comment |
Organism |
Structure |
---|
1.8.1.7 |
0.089 |
- |
glutathione disulfide |
pH 7.8, 37°C |
Haemonchus contortus |
|
Metals/Ions
EC Number |
Metals/Ions |
Comment |
Organism |
Structure |
---|
1.8.1.7 |
additional information |
Ba2+, Mn2+, and Mg2+ in a range of 0.01-5 mM have no effect on TrxR3 activity |
Haemonchus contortus |
|
Molecular Weight [Da]
EC Number |
Molecular Weight [Da] |
Molecular Weight Maximum [Da] |
Comment |
Organism |
---|
1.8.1.7 |
134000 |
- |
gel filtration |
Haemonchus contortus |
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
1.8.1.7 |
Haemonchus contortus |
CDJ91018 |
thioredoxin reductase, EC 1.8.1.9, with additional glutathione reductase activity |
- |
Purification (Commentary)
EC Number |
Purification (Comment) |
Organism |
---|
1.8.1.7 |
- |
Haemonchus contortus |
Specific Activity [micromol/min/mg]
EC Number |
Specific Activity Minimum [µmol/min/mg] |
Specific Activity Maximum [µmol/min/mg] |
Comment |
Organism |
---|
1.8.1.7 |
0.118 |
- |
pH 7.8, 37°C |
Haemonchus contortus |
Substrates and Products (Substrate)
EC Number |
Substrates |
Comment Substrates |
Organism |
Products |
Comment (Products) |
Rev. |
Reac. |
---|
1.8.1.7 |
glutathione disulfide + NADPH + H+ |
- |
Haemonchus contortus |
2 glutathione + NADP+ |
- |
? |
|
Subunits
EC Number |
Subunits |
Comment |
Organism |
---|
1.8.1.7 |
dimer |
2 * 67000, SDS-PAGE |
Haemonchus contortus |
Synonyms
EC Number |
Synonyms |
Comment |
Organism |
---|
1.8.1.7 |
HCOI_01258400 |
- |
Haemonchus contortus |
1.8.1.7 |
TrxR3 |
- |
Haemonchus contortus |
Temperature Stability [°C]
EC Number |
Temperature Stability Minimum [°C] |
Temperature Stability Maximum [°C] |
Comment |
Organism |
---|
1.8.1.7 |
37 |
- |
stable for 20 min |
Haemonchus contortus |
Turnover Number [1/s]
EC Number |
Turnover Number Minimum [1/s] |
Turnover Number Maximum [1/s] |
Substrate |
Comment |
Organism |
Structure |
---|
1.8.1.7 |
2.95 |
- |
glutathione disulfide |
pH 7.8, 37°C |
Haemonchus contortus |
|
Cofactor
EC Number |
Cofactor |
Comment |
Organism |
Structure |
---|
1.8.1.7 |
NADPH |
- |
Haemonchus contortus |
|
IC50 Value
EC Number |
IC50 Value |
IC50 Value Maximum |
Comment |
Organism |
Inhibitor |
Structure |
---|
1.8.1.7 |
0.92 |
- |
pH 7.8, 37°C |
Haemonchus contortus |
Zn2+ |
|
kcat/KM [mM/s]
EC Number |
kcat/KM Value [1/mMs-1] |
kcat/KM Value Maximum [1/mMs-1] |
Substrate |
Comment |
Organism |
Structure |
---|
1.8.1.7 |
2.95 |
- |
glutathione disulfide |
pH 7.8, 37°C |
Haemonchus contortus |
|