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Literature summary extracted from

  • Bonaiuto, E.; Milelli, A.; Cozza, G.; Tumiatti, V.; Marchetti, C.; Agostinelli, E.; Fimognari, C.; Hrelia, P.; Minarini, A.; Di Paolo, M.L.
    Novel polyamine analogues from substrates towards potential inhibitors of monoamine oxidases (2013), Eur. J. Med. Chem., 70, 88-101 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.4 Clorgyline irreversible inhibitor of isoform MAO A Homo sapiens
1.4.3.4 isatin competitive inhibitor; competitive inhibitor Homo sapiens
1.4.3.4 N-benzyl-12-isothiocyanato-N-methyldodecan-1-amine irreversible inhibition with respect to isoform MAO-A, competitive inhibition with respect to isoform MAO-B; irreversible inhibition with respect to isoform MAO-A, competitive inhibition with respect to isoform MAO-B Homo sapiens
1.4.3.4 N1,N12-dibenzyldodecane-1,12-diamine
-
 Homo sapiens
1.4.3.4 N1-(3-aminopropyl)-N4-(3-((naphthalen-2-ylmethyl)amino)propyl)butane-1,4-diamine
-
 Homo sapiens
1.4.3.4 N1-(3-aminopropyl)-N4-(3-((pyridin-3-ylmethyl)amino)propyl)butane-1,4-diamine
-
 Homo sapiens
1.4.3.4 N1-(3-aminopropyl)-N4-(3-((thiophen-2-ylmethyl)amino)propyl)butane-1,4-diamine mixed-type reversible inhibition with respect to isoform MAO-A and MAO-B; mixed-type reversible inhibition with respect to isoform MAO-A and MAO-B Homo sapiens
1.4.3.4 N1-benzyl-spermine
-
 Homo sapiens
1.4.3.4 selegiline irreversible inhibitor of isoform MAO B Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.4.3.4 0.012
-
 N1-benzyl-N1-methyldodecane-1,12-diamine isoform MAO B, at pH 7.4 and 37°C Homo sapiens
1.4.3.4 0.018
-
 N1-(thiophen-2-ylmethyl)dodecane-1,12-diamine isoform MAO B, at pH 7.4 and 37°C Homo sapiens
1.4.3.4 0.043
-
 N1-benzyldodecane-1,12-diamine isoform MAO A, at pH 7.4 and 37°C Homo sapiens
1.4.3.4 0.044
-
 N1-benzyl-N1-methyldodecane-1,12-diamine isoform MAO A, at pH 7.4 and 37°C Homo sapiens
1.4.3.4 0.05
-
 N1-benzyldodecane-1,12-diamine isoform MAO B, at pH 7.4 and 37°C Homo sapiens
1.4.3.4 0.08
-
 N1-(thiophen-2-ylmethyl)dodecane-1,12-diamine isoform MAO A, at pH 7.4 and 37°C Homo sapiens
1.4.3.4 0.401
-
 3-(4-(3-aminopropoxy)butoxy)-N-(thiophen-2-ylmethyl)propan-1-amine isoform MAO B, at pH 7.4 and 37°C Homo sapiens
1.4.3.4 1.2
-
 3-(4-(3-aminopropoxy)butoxy)-N-(thiophen-2-ylmethyl)propan-1-amine isoform MAO A, at pH 7.4 and 37°C Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.4 Homo sapiens P21397
-
-
1.4.3.4 Homo sapiens P27338
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.4 3-(4-(3-aminopropoxy)butoxy)-N-(thiophen-2-ylmethyl)propan-1-amine + H2O + O2
-
 Homo sapiens 3-(4-[3-[(thiophen-2-ylmethyl)amino]propoxy]butoxy)propanal + NH3 + H2O2
-
 ?
1.4.3.4 4-tyramine + H2O + O2 substrate for isoform MAO A Homo sapiens (4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 benzylamine + H2O + O2 substrate for isoform MAO B Homo sapiens benzaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 N1-(thiophen-2-ylmethyl)dodecane-1,12-diamine + H2O + O2
-
 Homo sapiens 12-[(thiophen-2-ylmethyl)amino]dodecanal + NH3 + H2O2
-
 ?
1.4.3.4 N1-benzyl-N1-methyldodecane-1,12-diamine + H2O + O2
-
 Homo sapiens 12-[benzyl(methyl)amino]dodecanal + NH3 + H2O2
-
 ?
1.4.3.4 N1-benzyldodecane-1,12-diamine + H2O + O2
-
 Homo sapiens 12-(benzylamino)dodecanal + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.4 MAO A
-
 Homo sapiens
1.4.3.4 MAO B
-
 Homo sapiens
1.4.3.4 monoamine oxidase A
-
 Homo sapiens
1.4.3.4 monoamine oxidase B
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.3.4 FAD
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.4.3.4 0.000012
-
 Clorgyline isoform MAO A, at pH 7.4 and 37°C Homo sapiens
1.4.3.4 0.000055
-
 selegiline isoform MAO B, at pH 7.4 and 37°C Homo sapiens
1.4.3.4 0.002
-
 isatin isoform MAO B, at pH 7.4 and 37°C Homo sapiens
1.4.3.4 0.016
-
 isatin isoform MAO A, at pH 7.4 and 37°C Homo sapiens