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Literature summary extracted from

  • Schlotawa, L.; Radhakrishnan, K.; Baumgartner, M.; Schmid, R.; Schmidt, B.; Dierks, T.; Gaertner, J.
    Rapid degradation of an active formylglycine generating enzyme variant leads to a late infantile severe form of multiple sulfatase deficiency (2013), Eur. J. Hum. Genet., 21, 1020-1023 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
1.8.3.7 E130D the mutation is associated with multiple sulfatase deficiency Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.8.3.7 endoplasmic reticulum
-
 Homo sapiens 5783
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.3.7 a [sulfatase]-L-cysteine + O2 + a thiol Homo sapiens
-
 a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.3.7 Homo sapiens Q8NBK3
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.8.3.7 HisTrap column chromatography, and Superdex 200 gel filtration Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.3.7 fibroblast
-
 Homo sapiens
-
1.8.3.7 HT-1080 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.3.7 a [sulfatase]-L-cysteine + O2 + a thiol
-
 Homo sapiens a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
1.8.3.7 ? x * 41000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.8.3.7 FGE
-
 Homo sapiens
1.8.3.7 formylglycine generating enzyme
-
 Homo sapiens
1.8.3.7 SUMF1
-
 Homo sapiens