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Literature summary extracted from

  • Fennema, D.; Phillips, I.R.; Shephard, E.A.
    Trimethylamine and trimethylamine N-oxide, a flavin-containing monooxygenase 3 (FMO3)-mediated host-microbiome metabolic axis implicated in health and disease (2016), Drug Metab. Dispos., 44, 1839-1850 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
1.14.13.8 E158K the mutant shows moderately reduced activity Homo sapiens
1.14.13.8 E308G the mutant shows moderately reduced activity Homo sapiens
1.14.13.8 L360P the mutation increases catalytic activity Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.8 Homo sapiens P31513
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.13.8 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.8 trimethylamine + NADPH + H+ + O2
-
 Homo sapiens trimethylamine N-oxide + NADP+ + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.13.8 flavin-containing monooxygenase 3
-
 Homo sapiens
1.14.13.8 FMO3
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.13.8 FAD
-
 Homo sapiens
1.14.13.8 NADPH
-
 Homo sapiens