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Literature summary extracted from

  • Phillips, I.R.; Francois, A.A.; Shephard, E.A.
    The flavin-containing monooxygenases (FMOs) genetic variation and its consequences for the metabolism of therapeutic drugs (2007), Curr. Pharmacogenomics, 5, 292-313 .
No PubMed abstract available

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.8 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.8 tamoxifen + NADPH + H+ + O2
-
 Homo sapiens ?
-
 ?
1.14.13.8 thiacetazone + NADPH + H+ + O2
-
 Homo sapiens ?
-
 ?
1.14.13.8 trimethylamine + NADPH + H+ + O2
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.13.8 FMO1 isoform Homo sapiens
1.14.13.8 FMO2 isoform Homo sapiens
1.14.13.8 FMO3 isoform Homo sapiens
1.14.13.8 FMO4 isoform Homo sapiens
1.14.13.8 FMO5 isoform Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.13.8 FAD
-
 Homo sapiens
1.14.13.8 NADPH
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.14.13.8 malfunction mutations in isoform FMO3 are causative of the disorder trimethylaminuria Homo sapiens