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Literature summary extracted from

  • Ueda, D.; Yamaga, H.; Murakami, M.; Totsuka, Y.; Shinada, T.; Sato, T.
    Biosynthesis of sesterterpenes, head-to-tail triterpenes, and sesquarterpenes in Bacillus clausii Identification of multifunctional enzymes and analysis of isoprenoid metabolites (2015), ChemBioChem, 16, 1371-1377 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.3.130 all-trans-heptaprenyl diphosphate Alkalihalobacillus clausii
-
 tetraprenyl-beta-curcumene + diphosphate
-
 ?
4.2.3.188 all-trans-geranylfarnesyl diphosphate Alkalihalobacillus clausii
-
 beta-geranylfarnesene + diphosphate
-
 ?
4.2.3.188 all-trans-geranylfarnesyl diphosphate Alkalihalobacillus clausii KSM-K16
-
 beta-geranylfarnesene + diphosphate
-
 ?
4.2.3.188 all-trans-heptaprenyl diphosphate Alkalihalobacillus clausii
-
 beta-heptaprene + diphosphate
-
 ?
4.2.3.188 all-trans-heptaprenyl diphosphate Alkalihalobacillus clausii KSM-K16
-
 beta-heptaprene + diphosphate
-
 ?
4.2.3.188 all-trans-hexaprenyl diphosphate Alkalihalobacillus clausii
-
 beta-hexaprene + diphosphate
-
 ?
4.2.3.188 all-trans-hexaprenyl diphosphate Alkalihalobacillus clausii KSM-K16
-
 beta-hexaprene + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.3.130 Alkalihalobacillus clausii
-
-
-
4.2.3.188 Alkalihalobacillus clausii Q5WIP9 trifunctional sesterterpene/triterpene/sesquarterpene synthase
-
4.2.3.188 Alkalihalobacillus clausii KSM-K16 Q5WIP9 trifunctional sesterterpene/triterpene/sesquarterpene synthase
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.3.130 all-trans-heptaprenyl diphosphate
-
 Alkalihalobacillus clausii tetraprenyl-beta-curcumene + diphosphate
-
 ?
4.2.3.130 additional information Bcl-TS is a sesterterpene (C25)/triterpene (C30) synthase, the enzyme catalyzes the conversion of (all-E)-geranylfarnesyl diphosphate (GFPP) and (all-E)-hexaprenyl diphosphate (HexPP) into beta-geranylfarnesene and beta-hexaprene in a head-to-tail triterpene synthase. NMR spectroscopic and TLC analysis of radiolabeled products, overview. Enzyme Bcl-TS can accept HepPP (C35) as a substrate and cyclizes HepPP (C35) to a monocycle Alkalihalobacillus clausii ?
-
 ?
4.2.3.188 all-trans-geranylfarnesyl diphosphate
-
 Alkalihalobacillus clausii beta-geranylfarnesene + diphosphate
-
 ?
4.2.3.188 all-trans-geranylfarnesyl diphosphate
-
 Alkalihalobacillus clausii KSM-K16 beta-geranylfarnesene + diphosphate
-
 ?
4.2.3.188 all-trans-heptaprenyl diphosphate
-
 Alkalihalobacillus clausii beta-heptaprene + diphosphate
-
 ?
4.2.3.188 all-trans-heptaprenyl diphosphate
-
 Alkalihalobacillus clausii KSM-K16 beta-heptaprene + diphosphate
-
 ?
4.2.3.188 all-trans-hexaprenyl diphosphate
-
 Alkalihalobacillus clausii beta-hexaprene + diphosphate
-
 ?
4.2.3.188 all-trans-hexaprenyl diphosphate
-
 Alkalihalobacillus clausii KSM-K16 beta-hexaprene + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.3.130 Bcl-TS
-
 Alkalihalobacillus clausii
4.2.3.130 sesterterpene/triterpene/sesquarterpene synthase
-
 Alkalihalobacillus clausii

General Information

EC Number General Information Comment Organism
4.2.3.130 metabolism GFPP and HexPP, the enzyme Bcl-TS substrates, are biosynthesized by enzymes E-IDS2-S/L in Bacillus clausii, and the tetraprenyl-beta-curcumene cyclase forms baciterpenol A from tetraprenyl-beta-curcumene. Proposed pathways for the biosynthesis of acyclic terpenes and menaquinones by Bacillus clausii, overview Alkalihalobacillus clausii
4.2.3.130 additional information only one sesterterpene synthase (ophiobolin F synthase, EC 4.2.3.145) that utilizes GFPP as a substrate has been identified other than Bcl-TS to date Alkalihalobacillus clausii
4.2.3.130 physiological function the tetraprenyl-beta-curcumene synthase homologue from Bacillus clausii (Bcl-TS) catalyzes the conversion of (all-E)-geranylfarnesyl diphosphate (GFPP) and (all-E)-hexaprenyl diphosphate (HexPP) into beta-geranylfarnesene and beta-hexaprene, respectively, in vitro, and both compounds are produced in Bacillus clausii. THe enzyme is involved in the biosynthesis of menaquinones Alkalihalobacillus clausii