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Literature summary extracted from

  • Saraav, I.; Pandey, K.; Misra, R.; Singh, S.; Sharma, M.; Sharma, S.
    Characterization of MymA protein as a flavin-containing monooxygenase and as a target of isoniazid (2017), Chem. Biol. Drug Des., 89, 152-160 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.13.8 isoniazid
-
 Mycobacterium tuberculosis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.13.8 0.0202
-
 trimethylamine at pH 8.0 and 30°C Mycobacterium tuberculosis
1.14.13.8 0.0385
-
 Thiourea at pH 8.0 and 30°C Mycobacterium tuberculosis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.13.8 cell wall
-
 Mycobacterium tuberculosis 5618
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.8 Mycobacterium tuberculosis
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.13.8 Ni-NTA column chromatography Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.8 additional information no activity with glutathione Mycobacterium tuberculosis ?
-
 ?
1.14.13.8 thiourea + NADPH + H+ + O2
-
 Mycobacterium tuberculosis ?
-
 ?
1.14.13.8 trimethylamine + NADPH + H+ + O2
-
 Mycobacterium tuberculosis ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.14.13.8 ? x * 55500, SDS-PAGE Mycobacterium tuberculosis

Synonyms

EC Number Synonyms Comment Organism
1.14.13.8 FMO
-
 Mycobacterium tuberculosis
1.14.13.8 MymA
-
 Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.13.8 FAD
-
 Mycobacterium tuberculosis
1.14.13.8 NADPH
-
 Mycobacterium tuberculosis

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.13.8 0.0049
-
 at pH 8.0 and 30°C Mycobacterium tuberculosis isoniazid