Any feedback?
Literature summary extracted from
- Redox modulation by reversal of the mitochondrial nicotinamide nucleotide transhydrogenase (2015), Cell Metab., 22, 363-365 .
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 7.1.1.1 | using 30% (w/v) PEG 400 in 0.1 M MES pH 6.5 with 0.1-0.4 M magnesium nitrate and 1 to 2.5% benzamidine hydrochloride | Thermus thermophilus |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 7.1.1.1 | T214A | the mutant shows 5% or less of wild type activity | Thermus thermophilus |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 7.1.1.1 | membrane | - |
Thermus thermophilus | 16020 | - |
| 7.1.1.1 | mitochondrion | - |
Mus musculus | 5739 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.1.1.1 | NADPH + NAD+ + H+[side 1] | Mus musculus | - |
NADP+ + NADH + H+[side 2] | - |
? |  |
| 7.1.1.1 | NADPH + NAD+ + H+[side 1] | Thermus thermophilus | - |
NADP+ + NADH + H+[side 2] | - |
? | |
| 7.1.1.1 | NADPH + NAD+ + H+[side 1] | Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039 | - |
NADP+ + NADH + H+[side 2] | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.1.1.1 | Mus musculus | - |
- |
- |
| 7.1.1.1 | Thermus thermophilus | Q72GS0 | subunit beta | - |
| 7.1.1.1 | Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039 | Q72GS0 | subunit beta | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 7.1.1.1 | - |
Thermus thermophilus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.1.1.1 | NADPH + NAD+ + H+[side 1] | - |
Mus musculus | NADP+ + NADH + H+[side 2] | - |
? | |
| 7.1.1.1 | NADPH + NAD+ + H+[side 1] | - |
Thermus thermophilus | NADP+ + NADH + H+[side 2] | - |
? | |
| 7.1.1.1 | NADPH + NAD+ + H+[side 1] | - |
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039 | NADP+ + NADH + H+[side 2] | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 7.1.1.1 | nicotinamide nucleotide transhydrogenase | - |
Mus musculus |
| 7.1.1.1 | nicotinamide nucleotide transhydrogenase | - |
Thermus thermophilus |
| 7.1.1.1 | NNT | - |
Mus musculus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 7.1.1.1 | 8 | - |
- |
Thermus thermophilus |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 7.1.1.1 | physiological function | the enzyme couples electron movement between the NADP/NADPH and NAD/NADH pools to the protonmotive force across the mitochondrial inner membrane | Mus musculus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
