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Literature summary extracted from

  • Kang, D.M.; Tanaka, K.; Takenaka, S.; Ishikawa, S.; Yoshida, K.I.
    Bacillus subtilis iolU encodes an additional NADP(+)-dependent scyllo-inositol dehydrogenase (2017), Biosci. Biotechnol. Biochem., 81, 1026-1032 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.371 gene iolW, DNA and amino acid sequence determination and analysis, the gene belongs to the Gfo/Idh/MocA family Bacillus subtilis
1.1.1.371 gene yulF, DNA and amino acid sequence determination and analysis, the gene belongs to the Gfo/Idh/MocA family, recombinant expression of His6-tagged YulF Bacillus subtilis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.371 scyllo-inositol + NADP+ Bacillus subtilis
-
 2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+
-
 ?
1.1.1.371 scyllo-inositol + NADP+ Bacillus subtilis 168
-
 2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.371 Bacillus subtilis O05265
-
-
1.1.1.371 Bacillus subtilis O32223
-
-
1.1.1.371 Bacillus subtilis 168 O05265
-
-
1.1.1.371 Bacillus subtilis 168 O32223
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.371 scyllo-inositol + NADP+
-
 Bacillus subtilis 2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+
-
 ?
1.1.1.371 scyllo-inositol + NADP+ recombinant His6-tagged YulF converts scyllo-inosose into SI in an NADPH-dependent manner Bacillus subtilis 2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+
-
 ?
1.1.1.371 scyllo-inositol + NADP+
-
 Bacillus subtilis 168 2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+
-
 ?
1.1.1.371 scyllo-inositol + NADP+ recombinant His6-tagged YulF converts scyllo-inosose into SI in an NADPH-dependent manner Bacillus subtilis 168 2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.371 iolU
-
 Bacillus subtilis
1.1.1.371 IolW
-
 Bacillus subtilis
1.1.1.371 NADP+-dependent SI dehydrogenase
-
 Bacillus subtilis
1.1.1.371 yulF
-
 Bacillus subtilis

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.371 NADP+
-
 Bacillus subtilis

General Information

EC Number General Information Comment Organism
1.1.1.371 evolution IolW shares a significant similarity with YulF, another NADP+-dependent SI dehydrogenase Bacillus subtilis
1.1.1.371 evolution YulF shares a significant similarity with IolW, another NADP+-dependent SI dehydrogenase Bacillus subtilis
1.1.1.371 additional information when yulF is overexpressed instead of iolW in the Bacillus subtilis cell factory, scyllo-inositol is produced from myo-inositol, suggesting a similar function to iolW Bacillus subtilis