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Literature summary extracted from

  • Watanabe, G.; Nakajima, D.; Hiroshima, A.; Suzuki, H.; Yoneda, S.
    Analysis of water channels by molecular dynamics simulation of heterotetrameric sarcosine oxidase (2015), Biophys. Physicobiol., 12, 131-137 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.3.1 sarcosine + H2O + O2 Corynebacterium sp. U-96
-
 glycine + formaldehyde + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.5.3.1 Corynebacterium sp. U-96 Q50LF0 and Q50LF2 and Q50LF1 and Q50LE9 Q50LF0: subunit alpha, Q50LF2: subunit beta, Q50LF1: subunit delta, Q50LE9: subunit gamma
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.5.3.1 sarcosine + H2O + O2 = glycine + formaldehyde + H2O2 molecular dynamics simulation study for the heterotetrameric sarcosine oxidase-dimethylglycine complex gives insight to understand the dynamics of the enzyme. A cluster analysis on the small rectangular cells with high water probabilities results in the detection of eleven water channels. CH1, CH2, CH3, and CH4 correspond to the tunnels from the large cavity in the previous study. CH6, CH7, and the combined CH8 and CH9 are narrow channels from the large cavity. CH5 and the combined CH10 and CH11 are not connected with the cavity. No permeation of water molecules between the channels is found except in the combined channels. The results of the present analysis are consistent with the selective transport hypothesis Corynebacterium sp. U-96
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.3.1 sarcosine + H2O + O2
-
 Corynebacterium sp. U-96 glycine + formaldehyde + H2O2
-
 ?

Subunits

EC Number Subunits Comment Organism
1.5.3.1 heterotetramer
-
 Corynebacterium sp. U-96

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.3.1 FAD flavoprotein. The flavin is both covalently and non-covalently bound in a molar ratio of 1:1 Corynebacterium sp. U-96