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Literature summary extracted from

  • Lehr, M.; Fabian, J.; Hanekamp, W.
    Involvement of microsomal NADPH-cytochrome P450 reductase in metabolic reduction of drug ketones (2015), Biopharm. Drug Dispos., 36, 398-404 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.6.2.4 alpha-lipoic acid 17% inhibition at 5.0 mM Homo sapiens
1.6.2.4 Ethacrynic acid 64% inhibition at 1.0 mM Homo sapiens
1.6.2.4 menadione 85% inhibition at 0.2 mM Homo sapiens
1.6.2.4 additional information no significant inhibition by diphenyleneiodonium chloride, flufenamic acid, and 18beta-glycyrrhetinic acid Homo sapiens
1.6.2.4 phenolphthaleine 13% inhibition at 0.02 mM Homo sapiens
1.6.2.4 quercetin 48% inhibition at 0.2 mM Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.6.2.4 microsome
-
 Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.6.2.4 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.2.4 NADPH + H+ + 1-[3-(4-phenoxyphenoxy)-2-oxopropyl]indole-5-carboxylic acid
-
 Homo sapiens NADP+ + 1-[2-hydroxy-3-(4-phenoxyphenoxy)propyl]indole-5-carboxylic acid
-
 ?
1.6.2.4 NADPH + H+ + daunorubicin
-
 Homo sapiens NADP+ + ?
-
 ?
1.6.2.4 NADPH + H+ + haloperidol
-
 Homo sapiens NADP+ + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.6.2.4 NADPH-CYP450 reductase
-
 Homo sapiens
1.6.2.4 NADPH-cytochrome P450 reductase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.6.2.4 FAD
-
 Homo sapiens
1.6.2.4 FMN
-
 Homo sapiens