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Literature summary extracted from

  • Reshma, R.S.; Saxena, S.; Bobesh, K.A.; Jeankumar, V.U.; Gunda, S.; Yogeeswari, P.; Sriram, D.
    Design and development of new class of Mycobacterium tuberculosis L-alanine dehydrogenase inhibitors (2016), Bioorg. Med. Chem., 24, 4499-4508 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.4.1.1
-
Mycobacterium tuberculosis

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.4.1.1 identificaion of putative inhibitors by molecular docking Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.1.1 1-(isonicotinamido)-N2,N4-bis(benzo[d]thiazol-2-yl)azetidine-2,4-dicarboxamide compound shows 100fold reduction in nutrient starved dormant Mycobacterium tuberculosis model and MIC of 11.81 microM in actively replicative Mycobacterium tuberculosis Mycobacterium tuberculosis
1.4.1.1 1-(isonicotinamido)-N2,N4-bis(phenyl)azetidine-2,4-dicarboxamide lead compound for inhibitor screening, involved in hydrophobic interactions with residues Pro242, Val241, Ala176, Leu130, Ile267, Ala179, Ile199 and Ile174 Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
1.4.1.1 Mycobacterium tuberculosis P9WQB1
-
-
1.4.1.1 Mycobacterium tuberculosis H37Rv P9WQB1
-
-

Synonyms

EC Number Synonyms Comment Organism
1.4.1.1 Rv2780
-
Mycobacterium tuberculosis

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.4.1.1 0.0038
-
pH not specified in the publication, temperature not specified in the publication Mycobacterium tuberculosis 1-(isonicotinamido)-N2,N4-bis(benzo[d]thiazol-2-yl)azetidine-2,4-dicarboxamide
1.4.1.1 0.0092
-
pH not specified in the publication, temperature not specified in the publication Mycobacterium tuberculosis 1-(isonicotinamido)-N2,N4-bis(phenyl)azetidine-2,4-dicarboxamide